澳大利亚的随机对照试验，通过短信进行行为推动，以增加孕妇对流感和COVID-19疫苗的吸收（EPIC研究）

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-07-09 DOI:10.1016/j.vaccine.2025.127477

Prabha H. Andraweera , Bing Wang , Margie Danchin , Christopher C. Blyth , Ivo Vlaev , Jason J. Ong , Jodie Dodd , Jennifer Couper , Thomas R. Sullivan , Alana R. Cuthbert , Jonathan Karnon , Nicola Spurrier , Michael Cusack , Dylan Mordaunt , Dimi Simatos , Gus Dekker , Samantha Carlson , Jane Tuckerman , Nicholas Wood , Lisa Whop , Helen S. Marshall

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引用次数: 0

摘要

背景孕妇的流感和COVID-19疫苗接种率不理想。我们评估了多成分行为助推干预对改善孕妇COVID-19和流感疫苗摄取的有效性。方法开发了一个“助推”，包括三条带有社会规范信息的短信提醒、疫苗安全信息链接、卫生专业人员和消费者建议在怀孕期间接种疫苗的视频，以及接种疫苗的承诺。在单独的随机对照试验中，在2023年流感季节未接种流感疫苗或接种了≤2剂COVID-19疫苗的孕妇被随机（1:1）分配到澳大利亚四家医院的标准护理或干预组。结果共有1090名孕妇和1068名孕妇被随机分为COVID-19和流感随机对照试验。轻推导致孕妇COVID-19疫苗接种率增加1.6%，流感疫苗接种率增加1.7%。然而，从随机分配到分娩，接受一剂COVID-19疫苗的干预组（2.7%）和标准护理组（1.1%）的孕妇百分比没有显著差异(优势比，2.40；95%置信区间[CI]， 0.91 ~ 6.30, P = 0.08)。同样，干预组（58.0%）和标准护理组（56.3%）的孕妇从随机分组到分娩时接种流感疫苗的比例也没有显著差异(优势比，1.07；95% CI, 0.84 ~ 1.38, P = 0.58)。在两项随机对照试验中，只有不到2%的女性观看了轻推的视频内容。结论短信推送导致孕妇COVID-19和流感疫苗接种率小幅上升。考虑到批量短信的成本非常低，这些推动在人口水平上可能是具有成本效益的干预措施。

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Randomised controlled trials of behavioural nudges delivered through text messages to increase influenza and COVID-19 vaccine uptake among pregnant women (EPIC study) in Australia

Background

Influenza and COVID-19 vaccine uptake among pregnant women is sub-optimal. We assessed the effectiveness of a multi-component behavioural nudge intervention to improve COVID-19 and influenza vaccine uptake among pregnant women.

Methods

A ‘nudge’ was developed that comprised three SMS text message reminders with a social norming message, links to vaccine safety information, videos of health professionals and consumers recommending vaccination in pregnancy and a pledge to get vaccinated. In separate RCTs, pregnant women who had not received an influenza vaccine during the 2023 influenza season, or received ≤2 doses of a COVID-19 vaccine, were randomised (1:1) to standard care or intervention at four hospitals in Australia.

Results

A total of 1090 and 1068 pregnant women were randomised to the COVID-19 and influenza RCTs, respectively. The nudges resulted in a 1.6 % increase in COVID-19 vaccine uptake and 1.7 % increase in influenza vaccine uptake among pregnant women. However, there was no significant difference in the percentage of pregnant women in the intervention (2.7 %) and the standard care (1.1 %) groups receiving one dose of a COVID-19 vaccine from randomisation until delivery (odds ratio, 2.40; 95 % confidence interval [CI], 0.91 to 6.30, P = 0.08). Similarly, there was no significant difference in the percentage of pregnant women in the intervention (58.0 %) and the standard care (56.3 %) groups receiving the influenza vaccine from the time of randomisation until delivery (odds ratio, 1.07; 95 % CI, 0.84 to 1.38, P = 0.58). Less than 2 % of women had viewed the video content of the nudges in both RCTs.

Conclusions

The nudges delivered via SMS resulted in small increases in COVID-19 and influenza vaccination uptake among pregnant women. Considering the very low cost of bulk SMS, these nudges may be cost-effective interventions at a population level.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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