植物细胞色素P450酶的生物活性代谢物合成、生长调控和逆境适应

IF 6.5 1区生物学 Q1 PLANT SCIENCES

Plant Physiology Pub Date : 2025-07-07 DOI:10.1093/plphys/kiaf297

Bo Liu, Zhaoyun Song, Xiaoquan Qi

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引用次数: 0

摘要

细胞色素P450酶（CYPs）是一类血红素单加氧酶，广泛分布于细菌、古细菌、病毒以及高等植物和动物中。它们调节各种内源物质和外源化合物的代谢，约占植物蛋白质编码基因的1%。这些酶在植物生物活性代谢产物的合成、生长调节和逆境适应等方面发挥着重要作用。目前，数据库中记录了超过30万个cyp，但只有一小部分（不到0.2%）进行了功能表征。本文从CYPs参与植物重要生物活性物质的生物合成以及在植物生长发育和逆境适应等方面的重要生理功能两方面综述了近年来CYPs的研究进展。目的是增强我们对CYPs在植物中的功能探索的认识和提供实例，从而为在生物技术育种和合成生物学领域的创新应用铺平道路。

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Plant Cytochrome P450 Enzymes for Bioactive Metabolites Biosynthesis, Growth Regulation and Stress Adaptation

Cytochrome P450 enzymes (CYPs), a class of heme monooxygenases, are widely distributed across bacteria, archaea, viruses, as well as in higher plants and animals. They regulate the metabolism of various endogenous substances and exogenous compounds, accounting for approximately 1% of the protein-coding genes in plants. These enzymes play a crucial role in the biosynthesis of plant bioactive metabolites, growth regulation and stress adaptation. Currently, over 300,000 CYPs are recorded in databases, yet only a small fraction (less than 0.2 %) has undergone functional characterization. This review will summarize the latest research progress from two perspectives: the involvement of CYPs in the biosynthesis of important bioactive compounds in plants, and their significant physiological functions in plant growth, development, and stress adaptation. The aim is to enhance our understanding and provide examples for the functional exploration of CYPs in plants, thereby paving the way for innovative applications in the field of biotechnological breeding and synthetic biology.

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来源期刊

Plant Physiology 生物-植物科学

CiteScore

12.20

自引率

5.40%

发文量

535

审稿时长

2.3 months

期刊介绍： Plant Physiology® is a distinguished and highly respected journal with a rich history dating back to its establishment in 1926. It stands as a leading international publication in the field of plant biology, covering a comprehensive range of topics from the molecular and structural aspects of plant life to systems biology and ecophysiology. Recognized as the most highly cited journal in plant sciences, Plant Physiology® is a testament to its commitment to excellence and the dissemination of groundbreaking research. As the official publication of the American Society of Plant Biologists, Plant Physiology® upholds rigorous peer-review standards, ensuring that the scientific community receives the highest quality research. The journal releases 12 issues annually, providing a steady stream of new findings and insights to its readership.