Harsha Shah, Jessica Phillips, Mandish K Dhanjal, Pooja Dassan, Michael Seckl, Charlotte Frise
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Radiation-induced brain necrosis during pregnancy: a delayed complication of gestational trophoblastic neoplasia.
Radiation-induced brain necrosis (RIBN) is a rare but serious delayed complication of intracerebral radiotherapy. We present the case of a 34-year-old woman with a history of gestational trophoblastic neoplasia (GTN) with brain metastases, who presented with symptoms related to RIBN at 20 weeks' gestation in a subsequent pregnancy. These included right homonymous inferior quadrantanopia and headaches. We describe the imaging and diagnostic tests used to assess for GTN recurrence and the specific management of RIBN in pregnancy within a multidisciplinary care setting.
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