Ferroptosis Related Serum Gpx4 Correlates to Severity of Coronary Artery Stenosis, and in-Stent Restenosis in Patients.

This study aimed to explore the association between serum ferritin and glutathione peroxidase 4 (Gpx4), markers of ferroptosis, with the severity of coronary artery stenosis and the occurrence of in-stent restenosis after percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients. The study encompassed 396 eligible CAD patients who underwent PCI, followed up for one year. A control group of 100 individuals was selected, matching the baseline data of CAD patients. Compared to healthy controls (HC), CAD patients showed a significant decrease in serum Gpx4 levels and an increase in ferritin levels. Significant disparities were observed in low-density lipoprotein cholesterol, Gensini score, serum Gpx4, and ferritin between the restenosis and no-restenosis groups (p < 0.001). Serum levels of ferritin and Gpx4, markers associated with ferroptosis, correlate with the severity of coronary artery stenosis in CAD patients and the occurrence of in-stent restenosis after PCI.