Xianqiong Lu, Qiyuan Luo, Danfeng Yu, Yan He, Jiyu Chen
{"title":"乳酸和乳酸化修饰在动脉粥样硬化性心血管疾病病理生理中的新作用。","authors":"Xianqiong Lu, Qiyuan Luo, Danfeng Yu, Yan He, Jiyu Chen","doi":"10.1007/s10557-025-07732-y","DOIUrl":null,"url":null,"abstract":"<p><p>Atherosclerosis is a chronic disease that is characterized by lipid accumulation and inflammation in the arterial wall. Atherosclerotic plaques form beneath the intima of large and medium-sized arteries and this is a leading cause of ischemic heart disease and stroke. Recently, with the intensification of global aging trends, the prevalence of atherosclerosis has increased significantly. Lactate, which is a byproduct of glycolysis, plays crucial roles in cell signaling, inflammatory responses, and metabolic regulation. Research on lactate and lactylation modifications in atherosclerotic cardiovascular diseases has gradually gained attention. This article reviews the latest research progress on lactate and its modifications in atherosclerotic cardiovascular diseases; explores mechanisms in pathological processes such as inflammation, oxidative stress, and apoptosis; and analyzes the potential as biomarkers and therapeutic targets. This review provides a reference for further studies on the role of lactate and lactylation in atherosclerotic cardiovascular diseases.</p>","PeriodicalId":9557,"journal":{"name":"Cardiovascular Drugs and Therapy","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Emerging Role of Lactate and Lactylation Modifications in the Pathophysiology of Atherosclerotic Cardiovascular Diseases.\",\"authors\":\"Xianqiong Lu, Qiyuan Luo, Danfeng Yu, Yan He, Jiyu Chen\",\"doi\":\"10.1007/s10557-025-07732-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Atherosclerosis is a chronic disease that is characterized by lipid accumulation and inflammation in the arterial wall. Atherosclerotic plaques form beneath the intima of large and medium-sized arteries and this is a leading cause of ischemic heart disease and stroke. Recently, with the intensification of global aging trends, the prevalence of atherosclerosis has increased significantly. Lactate, which is a byproduct of glycolysis, plays crucial roles in cell signaling, inflammatory responses, and metabolic regulation. Research on lactate and lactylation modifications in atherosclerotic cardiovascular diseases has gradually gained attention. This article reviews the latest research progress on lactate and its modifications in atherosclerotic cardiovascular diseases; explores mechanisms in pathological processes such as inflammation, oxidative stress, and apoptosis; and analyzes the potential as biomarkers and therapeutic targets. This review provides a reference for further studies on the role of lactate and lactylation in atherosclerotic cardiovascular diseases.</p>\",\"PeriodicalId\":9557,\"journal\":{\"name\":\"Cardiovascular Drugs and Therapy\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiovascular Drugs and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10557-025-07732-y\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiovascular Drugs and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10557-025-07732-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
The Emerging Role of Lactate and Lactylation Modifications in the Pathophysiology of Atherosclerotic Cardiovascular Diseases.
Atherosclerosis is a chronic disease that is characterized by lipid accumulation and inflammation in the arterial wall. Atherosclerotic plaques form beneath the intima of large and medium-sized arteries and this is a leading cause of ischemic heart disease and stroke. Recently, with the intensification of global aging trends, the prevalence of atherosclerosis has increased significantly. Lactate, which is a byproduct of glycolysis, plays crucial roles in cell signaling, inflammatory responses, and metabolic regulation. Research on lactate and lactylation modifications in atherosclerotic cardiovascular diseases has gradually gained attention. This article reviews the latest research progress on lactate and its modifications in atherosclerotic cardiovascular diseases; explores mechanisms in pathological processes such as inflammation, oxidative stress, and apoptosis; and analyzes the potential as biomarkers and therapeutic targets. This review provides a reference for further studies on the role of lactate and lactylation in atherosclerotic cardiovascular diseases.
期刊介绍：
Designed to objectively cover the process of bench to bedside development of cardiovascular drug, device and cell therapy, and to bring you the information you need most in a timely and useful format, Cardiovascular Drugs and Therapy takes a fresh and energetic look at advances in this dynamic field.
Homing in on the most exciting work being done on new therapeutic agents, Cardiovascular Drugs and Therapy focusses on developments in atherosclerosis, hyperlipidemia, diabetes, ischemic syndromes and arrhythmias. The Journal is an authoritative source of current and relevant information that is indispensable for basic and clinical investigators aiming for novel, breakthrough research as well as for cardiologists seeking to best serve their patients.
Providing you with a single, concise reference tool acknowledged to be among the finest in the world, Cardiovascular Drugs and Therapy is listed in Web of Science and PubMed/Medline among other abstracting and indexing services. The regular articles and frequent special topical issues equip you with an up-to-date source defined by the need for accurate information on an ever-evolving field. Cardiovascular Drugs and Therapy is a careful and accurate guide through the maze of new products and therapies which furnishes you with the details on cardiovascular pharmacology that you will refer to time and time again.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
