鞣花酸通过调节NF-κβ/COX-2和Nrf2/HO-1通路的抗氧化和抗炎机制保护雄性大鼠的胃溃疡。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2025-07-07 DOI:10.1080/13813455.2025.2529295

Mamdouh Eldesoqui, Emad A Albadawi, Amal F Dawood, Rania H M Soliman, Heba S Ahmed, Zeinab M Saeed, Nisreen E Elwany, Wesam M R Ashour, Mohamed Elshafey, Safa Mousa Al-Haider, Eman M A Abdelghany, Ahmed A El-Mansi, Sahar K Ali

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引用次数: 0

摘要

背景：胃溃疡通常由多种原因引起，包括压力。本研究考察了鞣花酸（EA）对应激性胃溃疡大鼠的胃保护作用。方法：40只雄性Wistar大鼠分为正常对照组、应激性溃疡组和EA治疗组（5 mg、10 mg、20 mg）。采用水浸应激模型诱发胃溃疡。进行了宏观和组织学评估，以及生化免疫组织化学研究。结果：EA治疗显著降低溃疡评分和指标，并呈剂量依赖性。EA降低TNF-α、IL-1β和MDA，增加PGE1和GSH。组织病理学评估证实了结果。免疫组化分析显示，ea处理组Nrf2和HO-1水平升高，NF-κB和COX-2水平降低。结论：EA通过其抗炎和抗氧化机制对应激性胃溃疡具有剂量依赖性的胃保护作用。

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Ellagic acid protects against gastric ulcer in male rats by antioxidant and anti-inflammatory mechanisms: modulation of NF-κβ/COX-2 and Nrf2/HO-1 pathways.

Background: Gastric ulcer is commonly affected by several causes, including stress. This work examined the gastroprotective effects of ellagic acid (EA), in stress-induced gastric ulcers in Wistar rats.

Methods: Forty male Wistar rats were categorized into five groups: a normal control group, a stress-induced ulcer group, and three groups receiving EA treatment (5 mg, 10 mg, and 20 mg). Gastric ulcers were elicited using a water immersion stress model. Macroscopic and histological assessments, together with biochemical immunohistochemical studies were performed.

Results: EA therapy markedly decreased ulcer scores and indices in a dose-dependent manner. EA decreased TNF-α, IL-1β and MDA and augmented PGE1 and GSH. Histopathological assessments verified the results. The immunohistochemical analysis revealed increased Nrf2 and HO-1 levels and decreased NF-κB and COX-2 levels in the EA-treated groups.

Conclusion: EA demonstrates gastroprotective properties against stress-induced gastric ulcers via its anti-inflammatory and antioxidant mechanisms in a dose-dependent manner.

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.