产前暴露于甲基苯丙胺及其与出生结局的关系:一项荟萃分析

IF 1.6 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Nima Rastegar-Pouyani, Fatemeh Fakhari, Armineh Rezagholi Lalani, Emad Jafarzadeh, Reza Zafari, Nader Rahimi, Ahmad Habibian Sezavar, Seyed Nasser Ostad
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引用次数: 0

摘要

甲基安非他明滥用现象日益普遍,因其对全世界公众健康的破坏性影响而被视为一个令人极为关切的问题。本研究旨在通过荟萃分析对文献进行系统回顾,以评估产前甲基苯丙胺暴露与早产(PTB)、低出生体重(LBW)和小胎龄(SGA)之间的关系。后来,我们调查了产前使用甲基苯丙胺和上述出生缺陷之间的关系。方法系统检索Web of Science、Scopus和PubMed网站从创办到2021年12月24日的英文文章,共1223篇观察性研究。去除重复后,仍有911篇文章进行标题和摘要筛选,其中868篇被排除。在对43项研究进行全文综述后,由于数据不足,35项研究被排除,剩下8项研究用于荟萃分析。使用Stata 15.0分析数据,以优势比(OR)(95%置信区间(CI))作为效应量。按样本类型(尿、胎便和…)进行亚组分析,并使用卡方检验评估异质性(I2大于50%被认为是异质性),相应应用固定效应或随机效应模型。通过Egger检验和漏斗图评估发表偏倚,并进行敏感性分析以评估结果的稳健性。结果产前暴露于甲基苯丙胺与PTB相关(OR 2.64;95% ci 1.89-3.70),体重(或2.83;95% CI 1.09-7.38)和SGA (OR 1.44;95% ci 1.04-1.99)。结论:我们的荟萃分析显示,产前暴露于甲基苯丙胺与PTB、LBW和SGA之间存在实质性关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prenatal Exposure to Methamphetamine and Its Association With Birth Outcomes: A Meta-Analysis

Purpose

The growing prevalence of methamphetamine abuse has been regarded as a matter of great concern due to its damaging impact on public health worldwide. Our study aimed to perform a systematic review of the literature with meta-analysis to evaluate the association between prenatal methamphetamine exposure, Preterm Birth (PTB) Low Birth Weight (LBW), and being Small for Gestational Age (SGA). Later on, we investigated the association between prenatal methamphetamine use and the aforementioned birth defects.

Methods

We conducted a systematic search of English-language articles in Web of Science, Scopus, and PubMed from inception to December 24, 2021, identifying 1223 observational studies. After removing duplicates, 911 articles remained for title and abstract screening, of which 868 were excluded. Following a full-text review of 43 studies, 35 were excluded due to insufficient data, leaving eight studies for meta-analysis. Data were analyzed using Stata 15.0, with Odds Ratio (OR) (95% Confidence Intervals (CI)) as effect sizes. Subgroup analysis was performed by sample type (urine, meconium, and …), and heterogeneity was assessed using the Chi-square test (I2 more than 50% was considered heterogenic), applying fixed- or random-effects models accordingly. Publication bias was evaluated via Egger's test and funnel plots, and sensitivity analysis was conducted to assess result robustness.

Results

Prenatal exposure to methamphetamine was found to be associated with PTB (OR 2.64; 95% CI 1.89–3.70), LBW (OR 2.83; 95% CI 1.09–7.38), and SGA (OR 1.44; 95% CI 1.04–1.99).

Conclusion

Our meta-analysis shows a substantial association between prenatal exposure to methamphetamine and PTB, LBW, and being SGA.

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来源期刊
Birth Defects Research
Birth Defects Research Medicine-Embryology
CiteScore
3.60
自引率
9.50%
发文量
153
期刊介绍: The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.
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