前言：全细胞溶酶体SMLM成像作为低光毒性自发闪烁探针的功能诊断指标

IF 16.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-07-07 DOI:10.1002/anie.202582801

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引用次数: 0

摘要

据Xiaogang Liu等人在其研究文章（e202503177）中报道，Aze-HMSiR是一种近红外自发闪烁荧光团，能够以最小的光毒性对溶酶体进行长期的SMLM成像。结合pH响应性和高光稳定性，它揭示了不同抗癌治疗下溶酶体的分布、大小和管腔pH等关键特征。这种全细胞成像方法为可视化溶酶体动力学提供了强大的新工具，并作为活细胞环境中功能诊断的敏感指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Frontispiece: Whole-Cell Lysosome SMLM Imaging as Indicators for Functional Diagnostics with a Low-Phototoxic Spontaneously Blinking Probe

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Frontispiece: Whole-Cell Lysosome SMLM Imaging as Indicators for Functional Diagnostics with a Low-Phototoxic Spontaneously Blinking Probe

Aze-HMSiR, a near-infrared spontaneously blinking fluorophore, enables long-term SMLM imaging of lysosomes with minimal phototoxicity, as reported by Xiaogang Liu et al. in their Research Article (e202503177). Combining pH responsiveness and high photostability, it reveals critical lysosomal features—distribution, size, and lumen pH—under different anticancer treatments. This whole-cell imaging approach provides a powerful new tool for visualizing lysosomal dynamics and serves as a sensitive indicator for functional diagnostics in live-cell environments.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.