注意缺陷多动障碍与儿童过敏：来自孟德尔随机化的证据

IF 1.8 4区医学 Q2 PEDIATRICS

Child Care Health and Development Pub Date : 2025-07-07 DOI:10.1111/cch.70135

Maolin Liu, Zhongyao Zeng, Yuanzhi Song, Yan Liu, Miao Sun, Guanghui Wei, Shengde Wu, Lihua Kou

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引用次数: 0

摘要

观察性研究报道了儿童注意缺陷多动障碍（ADHD）与过敏性疾病之间的关联，但这种关系是否反映因果关系尚不清楚。为了解决这个问题，我们使用与ADHD （N = 38691）和儿童过敏（N = 5337）相关的遗传工具变量进行了两样本双向孟德尔随机化（MR）分析，这些遗传工具变量来自最大的全基因组关联研究。使用反方差加权作为主要估计，而使用Cochran's Q检验和MR-Egger回归来检测异质性和多效性。结果主要MR估计显示ADHD与儿童变应性疾病风险显著相关（优势比= 1.14,95%可信区间：1.02 ~ 1.27,p = 0.017）。通过两步磁共振的中介分析显示，没有证据表明肠道微生物群和代谢物在ADHD对儿童过敏的影响中起中介作用。结论这些发现可能为ADHD儿童过敏性疾病的神经免疫相互作用和干预提供信息。

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Attention-Deficit Hyperactivity Disorder and Childhood Allergy: Evidence From Mendelian Randomization

Background

The association between attention-deficit hyperactivity disorder (ADHD) and allergic diseases in children has been reported in observational studies, yet whether the relationship reflects causality remains unclear.

Methods

To address this, we performed a two-sample bidirectional Mendelian randomization (MR) analysis using genetic instrumental variables associated with ADHD (N = 38 691) and childhood allergy (N = 5337) from the largest available genome-wide association studies. Inverse-variance weighted was used as the primary estimate, whereas Cochran's Q test and MR-Egger regression were used to detect heterogeneity and pleiotropy.

Results

The main MR estimates indicated that ADHD significantly associated with the risk of allergic diseases in children (odds ratio = 1.14, 95% confidence interval: 1.02–1.27, p = 0.017). The mediation analysis via two-step MR showed no evidence for mediating roles of gut microbiota and metabolites in the effect of ADHD on childhood allergy.

Conclusions

These findings may inform neuroimmune interaction and interventions for allergic diseases in children with ADHD.

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来源期刊

Child Care Health and Development 医学-小儿科

CiteScore

3.40

自引率

5.30%

发文量

136

审稿时长

4-8 weeks

期刊介绍： Child: care, health and development is an international, peer-reviewed journal which publishes papers dealing with all aspects of the health and development of children and young people. We aim to attract quantitative and qualitative research papers relevant to people from all disciplines working in child health. We welcome studies which examine the effects of social and environmental factors on health and development as well as those dealing with clinical issues, the organization of services and health policy. We particularly encourage the submission of studies related to those who are disadvantaged by physical, developmental, emotional and social problems. The journal also aims to collate important research findings and to provide a forum for discussion of global child health issues.