VDAC1在细胞死亡和存活中起Janus作用，膜联蛋白A5起拯救作用

IF 4.3 2区生物学 Q2 CELL BIOLOGY

Cell calcium Pub Date : 2025-07-03 DOI:10.1016/j.ceca.2025.103052

Ophélie Champion , Jacek J. Litewka , Pawel E. Ferdek , Geert Bultynck

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引用次数: 0

摘要

VDAC1是线粒体外膜上的一个大电导通道，在线粒体生理中起着至关重要的作用。VDAC1通过作为线粒体Ca2+摄取和atp退出系统支持细胞代谢和存活。相反，VDAC1也通过形成低聚孔介导细胞色素c的释放来促进细胞凋亡。最近，Oflaz等人，EMBO J， 2025发现Ca2+结合蛋白Annexin A5是一种动态的Ca2+依赖性开关，可增强VDAC1的Ca2+转运功能，同时阻止促凋亡VDAC1寡聚物的形成。

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VDAC1 as Janus in cell death and survival: Annexin A5 to the rescue

VDAC1, a large conductance channel in the outer mitochondrial membrane, plays a crucial role in mitochondrial physiology. VDAC1 supports cellular metabolism and survival by serving as a mitochondrial Ca²⁺-uptake and ATP-exit system. Conversely, VDAC1 also contributes to apoptosis by forming oligomeric pores mediating cytochrome c release. Recently, Oflaz et al., EMBO J, 2025, identified the Ca²⁺-binding protein Annexin A5 as a dynamic, Ca²⁺-dependent switch that enhances VDAC1’s Ca²⁺-transport function while at the same time preventing pro-apoptotic VDAC1 oligomer formation.

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来源期刊

Cell calcium 生物-细胞生物学

CiteScore

8.70

自引率

5.00%

发文量

115

审稿时长

35 days

期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes