从一对姐妹遭受自发性冠状动脉剥离（SCAD）的未受影响女性身上获得诱导多能干细胞系（VCCRIi024-A）

IF 0.8 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2025-07-05 DOI:10.1016/j.scr.2025.103770

Monique Bax , Keerat Junday , Emily Hurley , Stephanie Hesselson , Lucy McGrath-Cadell , Xenia Kaidonis , Ingrid Tarr , Eleni Giannoulatou , Siiri E. Iismaa , Robert M. Graham

{"title":"从一对姐妹遭受自发性冠状动脉剥离（SCAD）的未受影响女性身上获得诱导多能干细胞系（VCCRIi024-A）","authors":"Monique Bax , Keerat Junday , Emily Hurley , Stephanie Hesselson , Lucy McGrath-Cadell , Xenia Kaidonis , Ingrid Tarr , Eleni Giannoulatou , Siiri E. Iismaa , Robert M. Graham","doi":"10.1016/j.scr.2025.103770","DOIUrl":null,"url":null,"abstract":"<div><div>Spontaneous Coronary Artery Dissection (SCAD) is a poorly understood predominantly female condition that can cause myocardial infarction, often affecting otherwise healthy women. Here, we generated an induced pluripotent stem cell line from a female with two SCAD-affected sisters. This individual has not had a SCAD to date; she is currently 12 years older than when SCAD first manifested in her sisters. This resource provides a valuable control for investigating mechanisms underlying SCAD susceptibility.</div></div>","PeriodicalId":21843,"journal":{"name":"Stem cell research","volume":"87 ","pages":"Article 103770"},"PeriodicalIF":0.8000,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Generation of an induced pluripotent stem cell line from an unaffected female whose two sisters suffered spontaneous coronary artery dissections (SCAD) (VCCRIi024-A)\",\"authors\":\"Monique Bax , Keerat Junday , Emily Hurley , Stephanie Hesselson , Lucy McGrath-Cadell , Xenia Kaidonis , Ingrid Tarr , Eleni Giannoulatou , Siiri E. Iismaa , Robert M. Graham\",\"doi\":\"10.1016/j.scr.2025.103770\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Spontaneous Coronary Artery Dissection (SCAD) is a poorly understood predominantly female condition that can cause myocardial infarction, often affecting otherwise healthy women. Here, we generated an induced pluripotent stem cell line from a female with two SCAD-affected sisters. This individual has not had a SCAD to date; she is currently 12 years older than when SCAD first manifested in her sisters. This resource provides a valuable control for investigating mechanisms underlying SCAD susceptibility.</div></div>\",\"PeriodicalId\":21843,\"journal\":{\"name\":\"Stem cell research\",\"volume\":\"87 \",\"pages\":\"Article 103770\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Stem cell research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1873506125001205\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stem cell research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1873506125001205","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

自发性冠状动脉夹层（SCAD）是一种鲜为人知的主要女性疾病，可导致心肌梗死，通常影响其他健康女性。在这里，我们从一个女性和两个患有scad的姐妹中产生了一个诱导多能干细胞系。该患者至今未患SCAD；她现在比她姐姐第一次出现SCAD时大12岁。该资源为研究SCAD易感性的潜在机制提供了有价值的控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Generation of an induced pluripotent stem cell line from an unaffected female whose two sisters suffered spontaneous coronary artery dissections (SCAD) (VCCRIi024-A)

Spontaneous Coronary Artery Dissection (SCAD) is a poorly understood predominantly female condition that can cause myocardial infarction, often affecting otherwise healthy women. Here, we generated an induced pluripotent stem cell line from a female with two SCAD-affected sisters. This individual has not had a SCAD to date; she is currently 12 years older than when SCAD first manifested in her sisters. This resource provides a valuable control for investigating mechanisms underlying SCAD susceptibility.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.