大马士革玫瑰提取物口服胶囊对绝经期妇女抑郁、焦虑和压力的影响：一项随机对照试验

IF 3.9 2区医学 Q2 GERIATRICS & GERONTOLOGY

Maturitas Pub Date : 2025-07-04 DOI:10.1016/j.maturitas.2025.108659

Zohreh Gholinezhad, Fatemeh Zahra Karimi, Hassan Rakhshandeh, Seyed Reza Mazloum

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引用次数: 0

摘要

目的：在更年期，抑郁、焦虑和压力往往会增加。由于人们对副作用更小的草药替代药物越来越感兴趣，本研究旨在评估大马士革玫瑰提取物对更年期妇女抑郁、焦虑和压力的影响。方法：本三盲随机对照试验纳入82名年龄在45 - 60岁之间的自然绝经妇女，她们连续至少12个月没有月经，没有恶性肿瘤等严重疾病史。参与者被随机分配接受500毫克大马士革玫瑰提取物或安慰剂胶囊，每天两次，持续八周。在干预后的基线、4周和8周，使用抑郁、焦虑和压力量表- 21评估心理症状。数据采用SPSS 21版进行统计分析。结果干预组抑郁评分降低（从10.1±10.7降至3.9±4.6），而安慰剂组抑郁评分略有升高（从8.7±8.3降至9.6±7.5）(p <；0.001)。焦虑评分在干预组（从14.6±8.3降至6.2±4.8）比安慰剂组（从12.9±7.8降至12.2±7.8）下降更明显(p <；0.001)。干预组的应激水平下降（从19.0±9.3降至7.6±4.6），而安慰剂组的应激水平略有上升（从15.9±10.0升至17.6±9.0）(p <；0.001)。采用Bonferroni校正的事后分析显示，干预组在所有时间点上均存在显著差异(p <；0.05)。结论大马士革玫瑰提取物可作为一种有效且耐受性良好的草药干预措施，缓解绝经期妇女的抑郁、焦虑和压力。审判registrationIRCT20210208050295N1

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Effect of oral capsules of Rosa damascena mill extract on depression, anxiety and stress in menopausal women: A randomized controlled trial

Objective

Depression, anxiety, and stress often increase during menopause. Due to growing interest in herbal alternative medicines with fewer side-effects, this study aimed to assess the effect of Rosa damascena Mill extract on depression, anxiety, and stress in menopausal women.

Methods

This triple-blind randomized controlled trial included 82 naturally menopausal women between 45 and 60 years of age, who had not menstruated for at least 12 consecutive months and had no history of serious medical conditions such as malignancy. Participants were randomly assigned to receive either 500 mg Rosa damascena extract or placebo capsules twice daily for eight weeks. Psychological symptoms were evaluated using the Depression, Anxiety, and Stress Scale - 21 at baseline, 4, and 8 weeks after the intervention. The data were statistically analyzed using SPSS version 21.

Results

The intervention group demonstrated a statistically significant reduction in depression scores (from 10.1 ± 10.7 to 3.9 ± 4.6) whereas the placebo group showed a slight increase (from 8.7 ± 8.3 to 9.6 ± 7.5) (p < 0.001). Anxiety scores also declined more markedly in the intervention group (from 14.6 ± 8.3 to 6.2 ± 4.8) than in the placebo group (from 12.9 ± 7.8 to 12.2 ± 7.8) (p < 0.001). Stress levels decreased in the intervention group (from 19.0 ± 9.3 to 7.6 ± 4.6), while the placebo group showed a slight increase (15.9 ± 10.0 to 17.6 ± 9.0) (p < 0.001). Post-hoc analysis using Bonferroni correction revealed significant differences across all time points in the intervention group (p < 0.05).

Conclusion

Rosa damascena extract may serve as an effective and well-tolerated herbal intervention for mitigating depression, anxiety, and stress among menopausal women.

Trial registration

IRCT20210208050295N1

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来源期刊

Maturitas 医学-妇产科学

CiteScore

9.10

自引率

2.00%

发文量

142

审稿时长

40 days

期刊介绍： Maturitas is an international multidisciplinary peer reviewed scientific journal of midlife health and beyond publishing original research, reviews, consensus statements and guidelines, and mini-reviews. The journal provides a forum for all aspects of postreproductive health in both genders ranging from basic science to health and social care. Topic areas include:• Aging• Alternative and Complementary medicines• Arthritis and Bone Health• Cancer• Cardiovascular Health• Cognitive and Physical Functioning• Epidemiology, health and social care• Gynecology/ Reproductive Endocrinology• Nutrition/ Obesity Diabetes/ Metabolic Syndrome• Menopause, Ovarian Aging• Mental Health• Pharmacology• Sexuality• Quality of Life