三种不同脱敏膏处理外露颈牙本质的形态学及化学力学分析(体外比较研究)

Q1 Medicine
Manar S. Mohammad, Rasha H. Jehad
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引用次数: 0

摘要

背景:封堵牙本质小管是治疗牙本质过敏的一种有价值的方法。虽然各种各样的药物促进牙本质再矿化,但可可碱、生物活性玻璃(BAG)和纳米羟基磷灰石(Nano-HAP)在模拟口腔条件下的直接比较仍然有限。为了填补这一空白,本体外研究旨在评估和比较这三种治疗方法对外露颈牙本质的有效性。评估的重点是它们对牙本质的化学、形态学和力学影响。材料与方法从12颗健全的前磨牙颈段获得48块牙本质板。进行基线拉曼光谱和VMH测试以排除异常值。所有标本用6%柠檬酸(pH 2.0)处理2分钟,去除涂抹层。他们随机分为四组(n = 12):人工唾液(AS)、可可碱、BAG和纳米hap。通过拉曼光谱(960cm−1处磷酸盐峰强度)、维氏显微硬度测试(VMH)和扫描电镜(SEM)形态学评估进行评估。结果可可碱组、BAG组和纳米hap组的拉曼磷酸盐峰强度(960cm−1)和维氏显微硬度值(p <;0.05),表明表面再矿化。相比之下,人工唾液组磷酸盐峰强度和显微硬度值显著降低(p <;0.05)。结论与对照组相比,各药剂均显著提高了样品的拉曼磷酸峰和显微硬度值。纳米羟基磷灰石对牙本质表面再矿化的促进作用最大。在本研究的局限性内,可以得出结论,可可碱、BAG和纳米hap对牙本质小管的闭塞是有效的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Morphological & chemo mechanical analysis of exposed cervical dentin treated with three different desensitizing pastes (comparative in vitro study)

Background

Obstructing dentinal tubules is a valuable approach for managing dentin hypersensitivity. Although various agents promote dentin remineralization, direct comparisons between theobromine, bioactive glass (BAG), and nano-hydroxyapatite (Nano-HAP) under simulated oral conditions remain limited. To fill this gap, this in vitro study aimed to evaluate and compare the effectiveness of these three treatments on exposed cervical dentin. The assessment focused on their chemical, morphological, and mechanical effects on dentin.

Materials and methods

Forty-eight human dentin slabs were obtained from the cervical portions of twelve sound premolar teeth. Baseline Raman spectroscopy and VMH tests were done to exclude outliers. All specimens were treated with 6 % citric acid (pH 2.0) for 2 min to remove the smear layer. They randomly assigned to four groups (n = 12): artificial saliva (AS), theobromine, BAG, and Nano-HAP. Evaluations were conducted using Raman spectroscopy (phosphate peak intensity at 960cm−1), Vickers microhardness testing (VMH), and morphological assessment under scanning electron microscopy (SEM).

Results

Theobromine, BAG, and nano-HAP groups demonstrated a statistically significant increase in Raman phosphate peak intensity (960cm−1) and Vickers microhardness values (p < 0.05), indicating surface remineralization. In contrast, the artificial saliva group exhibited a significant decrease in phosphate peak intensity and microhardness values (p < 0.05).

Conclusion

All tested agents significantly enhanced the Raman phosphate peaks and microhardness values compared to the control. Nano-HAP showed the highest potential for promoting the remineralization of exposed dentin surfaces. Within the study's limitations, it can be concluded that theobromine, BAG, and nano-HAP are effective in occluding dentinal tubules.
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来源期刊
CiteScore
4.90
自引率
0.00%
发文量
133
审稿时长
167 days
期刊介绍: Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.
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