设计一种基于MWCNT/ZnS@CdS纳米复合材料的超灵敏免疫传感器，作为检测CEA生物标志物的电极表面修饰剂

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-07-03 DOI:10.1016/j.colsurfb.2025.114936

Ali Shamsazar , Mahsa Soheili Moghaddam , Nasim Jabbari , Behnam Babaei , Ramin Nasiri , Maryamosadat Mavaei

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引用次数: 0

摘要

在痕量分析物的检测中使用生物传感器技术引起了极大的兴趣。特别是，电化学免疫传感器为生物标志物的测量提供了一种准确有效的分析方法。癌胚抗原（CEA）是一种常用的生物标志物，用于监测结肠癌患者。在这项研究中，用多壁碳纳米管（MWCNTs）和ZnS@CdS核壳量子点（QDs）的纳米复合材料修饰了玻碳电极（GCE）的表面。由于这些纳米材料具有非常理想的物理化学性质，本研究设计的免疫传感器能够在0.0005至2.5 ng/mL的宽线性范围内检测CEA，检测限（LOD）为0.11 pg/mL。电极表面材料也具有良好的稳定性和性能。结合免疫传感器在CEA检测中的结果，可以推断这种新型生物传感器是一种很有前途的准确检测CEA的装置。

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Designing an ultrasensitive immunosensor based on MWCNT/ZnS@CdS nanocomposite as an electrode surface modifier for detection of CEA biomarker

The use of biosensor techniques in the detection of the analytes at trace amounts is of great interest. In particular, electrochemical immunosensors offer an accurate and efficient analytical method for the measurement of biomarkers. Carcinoembryonic antigen (CEA) is a biomarker commonly used in the monitoring of individuals with colon cancer. In this study, the surface of a glassy carbon electrode (GCE) was modified with a nanocomposite of multi-walled carbon nanotubes (MWCNTs) and ZnS@CdS core-shell quantum dots (QDs). Due to the highly desirable physicochemical properties of these nanomaterials, the immunosensor designed in this study demonstrated the ability to detect CEA in a wide linear range from 0.0005 to 2.5 ng/mL, with a limit of detection (LOD) of 0.11 pg/mL. The electrode surface materials also offered excellent stability and properties. Considering the results of the immunosensor in CEA assay, it can be inferred that this new biosensor is a promising device for accurate CEA detection.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.