中老年人抑郁症状轨迹与带状疱疹的关系：一项纵向国家队列研究

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research Pub Date : 2025-07-01 DOI:10.1016/j.jpsychores.2025.112307

Zirui Huang, Xiaoting Li, Jiahua Lin, Qike Ding, Tao Lu

{"title":"中老年人抑郁症状轨迹与带状疱疹的关系：一项纵向国家队列研究","authors":"Zirui Huang, Xiaoting Li, Jiahua Lin, Qike Ding, Tao Lu","doi":"10.1016/j.jpsychores.2025.112307","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Although depressive symptoms have been linked to an increased risk of herpes zoster (HZ), research specifically exploring the relationship between the trajectories of depressive symptoms and HZ is limited. We aim to investigate this association using data from the Health and Retirement Study (HRS).</div></div><div><h3>Methods</h3><div>We employed group-based trajectory modeling (GBTM) to categorize depressive symptom trajectories based on the 8-item CES-D scale in the HRS. The outcome, HZ incidence, was determined from Waves 10–15 of the HRS. Cox proportional-hazards regression was used to examine the association between the trajectories of depressive symptoms and HZ risk. Sensitivity and subgroup analyses assessed result robustness and effect modification.</div></div><div><h3>Results</h3><div>Depressive symptom trajectories were classified into three groups: persistently low (<em>n</em> = 5104), persistently moderate (<em>n</em> = 5357), and persistently high (<em>n</em> = 4405). Both persistently moderate and high depressive symptom trajectories were significantly associated with an increased risk of HZ, even after adjustment for covariates (moderate: HR = 1.24, 95 % CI: 1.02–1.51, <em>P</em> = 0.029; high: HR = 1.31, 95 % CI: 1.06–1.61, <em>P</em> = 0.011). Somatic symptoms were strongly associated with an increased HZ risk (HR = 1.31, 95 % CI: 1.08–1.59, <em>P</em> = 0.006). Subgroup analyses revealed stronger associations among men, non-smokers, ever drinkers, and individuals with higher education.</div></div><div><h3>Conclusion</h3><div>Persistently high depressive symptoms trajectories, including somatic domain, significantly increase HZ risk. These findings highlight the need to consider mental health as a modifiable risk factor for HZ, particularly in vulnerable populations.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"196 ","pages":"Article 112307"},"PeriodicalIF":3.3000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between depressive symptoms trajectories and herpes zoster in middle-aged and older adults: A longitudinal national cohort study\",\"authors\":\"Zirui Huang, Xiaoting Li, Jiahua Lin, Qike Ding, Tao Lu\",\"doi\":\"10.1016/j.jpsychores.2025.112307\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Although depressive symptoms have been linked to an increased risk of herpes zoster (HZ), research specifically exploring the relationship between the trajectories of depressive symptoms and HZ is limited. We aim to investigate this association using data from the Health and Retirement Study (HRS).</div></div><div><h3>Methods</h3><div>We employed group-based trajectory modeling (GBTM) to categorize depressive symptom trajectories based on the 8-item CES-D scale in the HRS. The outcome, HZ incidence, was determined from Waves 10–15 of the HRS. Cox proportional-hazards regression was used to examine the association between the trajectories of depressive symptoms and HZ risk. Sensitivity and subgroup analyses assessed result robustness and effect modification.</div></div><div><h3>Results</h3><div>Depressive symptom trajectories were classified into three groups: persistently low (<em>n</em> = 5104), persistently moderate (<em>n</em> = 5357), and persistently high (<em>n</em> = 4405). Both persistently moderate and high depressive symptom trajectories were significantly associated with an increased risk of HZ, even after adjustment for covariates (moderate: HR = 1.24, 95 % CI: 1.02–1.51, <em>P</em> = 0.029; high: HR = 1.31, 95 % CI: 1.06–1.61, <em>P</em> = 0.011). Somatic symptoms were strongly associated with an increased HZ risk (HR = 1.31, 95 % CI: 1.08–1.59, <em>P</em> = 0.006). Subgroup analyses revealed stronger associations among men, non-smokers, ever drinkers, and individuals with higher education.</div></div><div><h3>Conclusion</h3><div>Persistently high depressive symptoms trajectories, including somatic domain, significantly increase HZ risk. These findings highlight the need to consider mental health as a modifiable risk factor for HZ, particularly in vulnerable populations.</div></div>\",\"PeriodicalId\":50074,\"journal\":{\"name\":\"Journal of Psychosomatic Research\",\"volume\":\"196 \",\"pages\":\"Article 112307\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Psychosomatic Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022399925002715\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Psychosomatic Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022399925002715","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

摘要

背景：虽然抑郁症状与带状疱疹（HZ）风险增加有关，但专门探索抑郁症状轨迹与HZ之间关系的研究是有限的。我们的目的是利用健康与退休研究（HRS）的数据来调查这种关联。方法采用基于组的轨迹模型（GBTM）对HRS中8项ce - d量表的抑郁症状轨迹进行分类。结果，HZ发生率，由HRS的波10-15确定。Cox比例风险回归用于检验抑郁症状轨迹与HZ风险之间的关联。敏感性和亚组分析评估结果稳健性和效果修正。结果抑郁症状轨迹分为三组：持续轻度（n = 5104）、持续中度（n = 5357）和持续重度（n = 4405）。即使在调整协变量后，持续中度和高度抑郁症状轨迹都与HZ风险增加显著相关(中度：HR = 1.24, 95% CI: 1.02-1.51, P = 0.029；高：HR = 1.31, 95% CI: 1.06-1.61, P = 0.011)。躯体症状与HZ风险增加密切相关（HR = 1.31, 95% CI: 1.08-1.59, P = 0.006）。亚组分析显示，男性、非吸烟者、嗜酒者和受过高等教育的个体之间的相关性更强。结论持续高抑郁症状轨迹，包括躯体域，显著增加HZ风险。这些发现强调需要将精神健康视为HZ的可改变风险因素，特别是在弱势人群中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Association between depressive symptoms trajectories and herpes zoster in middle-aged and older adults: A longitudinal national cohort study

Background

Although depressive symptoms have been linked to an increased risk of herpes zoster (HZ), research specifically exploring the relationship between the trajectories of depressive symptoms and HZ is limited. We aim to investigate this association using data from the Health and Retirement Study (HRS).

Methods

We employed group-based trajectory modeling (GBTM) to categorize depressive symptom trajectories based on the 8-item CES-D scale in the HRS. The outcome, HZ incidence, was determined from Waves 10–15 of the HRS. Cox proportional-hazards regression was used to examine the association between the trajectories of depressive symptoms and HZ risk. Sensitivity and subgroup analyses assessed result robustness and effect modification.

Results

Depressive symptom trajectories were classified into three groups: persistently low (n = 5104), persistently moderate (n = 5357), and persistently high (n = 4405). Both persistently moderate and high depressive symptom trajectories were significantly associated with an increased risk of HZ, even after adjustment for covariates (moderate: HR = 1.24, 95 % CI: 1.02–1.51, P = 0.029; high: HR = 1.31, 95 % CI: 1.06–1.61, P = 0.011). Somatic symptoms were strongly associated with an increased HZ risk (HR = 1.31, 95 % CI: 1.08–1.59, P = 0.006). Subgroup analyses revealed stronger associations among men, non-smokers, ever drinkers, and individuals with higher education.

Conclusion

Persistently high depressive symptoms trajectories, including somatic domain, significantly increase HZ risk. These findings highlight the need to consider mental health as a modifiable risk factor for HZ, particularly in vulnerable populations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Psychosomatic Research 医学-精神病学

CiteScore

7.40

自引率

6.40%

发文量

314

审稿时长

6.2 weeks

期刊介绍： The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.