卡介苗加β-葡聚糖训练中性粒细胞对抗膀胱癌

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2025-07-07 DOI:10.1038/s41577-025-01209-7

Lucy Bird

引用次数: 0

摘要

卡介苗与β-葡聚糖结合后，其抗肿瘤作用显著增强。在膀胱癌小鼠模型中，联合治疗增强了粒细胞生成并训练中性粒细胞抵抗转化为原肿瘤表型。

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BCG plus β-glucan trains neutrophils to beat bladder cancer

The antitumoural effects of BCG can be vastly improved by combining it with β-glucan. The combination therapy enhances granulopoiesis and trains neutrophils to resist conversion into a protumoural phenotype in a mouse model of bladder cancer.

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.