肝硬化患者尿微生物群的微生物失调。

The American Journal of Gastroenterology Pub Date : 2025-07-07 DOI:10.14309/ajg.0000000000003634

Johannes Woltsche,Christian Pacher-Deutsch,Stefan Fürst,Lukas Gulden,Jakob Schwarzl,Nicole Feldbacher,Maximilian Nepel,Lavra Celcer,Natalie Hasl,Victoria Rieper,Vanessa Stadlbauer,Angela Horvath

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引用次数: 0

摘要

肝硬化与肠道以外的微生物组改变有关，包括皮肤、唾液和血清。本研究调查了肝硬化患者尿路微生物组（UMB），这些患者尿路感染（uti）的风险增加。方法采用16S rRNA测序对137例患者的中游尿液进行分析；68例肝硬化患者和32例非肝硬化对照符合纳入标准。结果肝硬化患者α -多样性明显降低。对照组的UMB在链球菌种类中富集。肝硬化患者微生物多样性减少和链球菌丰度降低可能有助于解释他们对尿路感染的易感性增加。

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Microbial Dysbiosis in the Urinary Microbiome of Patients with Cirrhosis.

INTRODUCTION Cirrhosis is associated with microbiome alterations beyond the gut, including skin, saliva, and serum. This study investigated the urinary microbiome (UMB) in patients with cirrhosis, who have an increased risk of urinary tract infections (UTIs). METHODS Midstream urine from 137 patients was analysed via 16S rRNA sequencing; 68 patients with cirrhosis and 32 non-cirrhotic controls met inclusion criteria. RESULTS Patients with cirrhosis showed significantly reduced alpha-diversity. The UMB of controls was enriched in Streptococcus species. DISCUSSION Reduced microbial diversity and lower Streptococcus abundance in patients with cirrhosis might help to explain their heightened susceptibility to UTIs.

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The American Journal of Gastroenterology

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