Ping Che, Siqi Wang, Xiaojiao Liu, Yunyao Lu, Zhuo Tian, Qixin Feng, Feifan Chen, Nan Zhang
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The plasma level of PlGF was measured via electrochemiluminescence immunoassay.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>The plasma PlGF level was significantly elevated in patients with SIVD compared with CUCs, and showed a high accuracy with an area under the curve of 0.893. Mediation analysis revealed that white matter hyperintensities (WMHs) volume mediated the effect of plasma PlGF levels on cognitive functions in a transdiagnostic cohort.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>The plasma PlGF is a potential biomarker for screening and diagnosing SIVD, and its correlation with cognitive function may be partly mediated by the WMHs.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Plasma placental growth factor (PlGF) showed high diagnostic value for subcortical ischemic vascular dementia.</li>\n \n <li>Plasma PlGF showed significantly negative correlation with cognition.</li>\n \n <li>White matter hyperintensities mediated the relationship between plasma PlGF and cognition.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 7","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70461","citationCount":"0","resultStr":"{\"title\":\"Plasma placental growth factor as a biomarker for subcortical ischemic vascular dementia and its cognitive correlation mediated by white matter hyperintensities\",\"authors\":\"Ping Che, Siqi Wang, Xiaojiao Liu, Yunyao Lu, Zhuo Tian, Qixin Feng, Feifan Chen, Nan Zhang\",\"doi\":\"10.1002/alz.70461\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>Placental growth factor (PlGF) was recently shown to be associated with cerebrovascular and neurodegenerative diseases. The changes of PlGF level in patients with subcortical ischemic vascular dementia (SIVD) and its associations with cognitive function remain unclear.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>Seventy patients with SIVD, 102 patients with symptomatic Alzheimer's disease, 40 patients with frontotemporal lobar degeneration, and 38 cognitively unimpaired controls (CUCs) were included. The plasma level of PlGF was measured via electrochemiluminescence immunoassay.</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>The plasma PlGF level was significantly elevated in patients with SIVD compared with CUCs, and showed a high accuracy with an area under the curve of 0.893. Mediation analysis revealed that white matter hyperintensities (WMHs) volume mediated the effect of plasma PlGF levels on cognitive functions in a transdiagnostic cohort.</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>The plasma PlGF is a potential biomarker for screening and diagnosing SIVD, and its correlation with cognitive function may be partly mediated by the WMHs.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Plasma placental growth factor (PlGF) showed high diagnostic value for subcortical ischemic vascular dementia.</li>\\n \\n <li>Plasma PlGF showed significantly negative correlation with cognition.</li>\\n \\n <li>White matter hyperintensities mediated the relationship between plasma PlGF and cognition.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 7\",\"pages\":\"\"},\"PeriodicalIF\":13.0000,\"publicationDate\":\"2025-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70461\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/alz.70461\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.70461","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Plasma placental growth factor as a biomarker for subcortical ischemic vascular dementia and its cognitive correlation mediated by white matter hyperintensities
INTRODUCTION
Placental growth factor (PlGF) was recently shown to be associated with cerebrovascular and neurodegenerative diseases. The changes of PlGF level in patients with subcortical ischemic vascular dementia (SIVD) and its associations with cognitive function remain unclear.
METHODS
Seventy patients with SIVD, 102 patients with symptomatic Alzheimer's disease, 40 patients with frontotemporal lobar degeneration, and 38 cognitively unimpaired controls (CUCs) were included. The plasma level of PlGF was measured via electrochemiluminescence immunoassay.
RESULTS
The plasma PlGF level was significantly elevated in patients with SIVD compared with CUCs, and showed a high accuracy with an area under the curve of 0.893. Mediation analysis revealed that white matter hyperintensities (WMHs) volume mediated the effect of plasma PlGF levels on cognitive functions in a transdiagnostic cohort.
DISCUSSION
The plasma PlGF is a potential biomarker for screening and diagnosing SIVD, and its correlation with cognitive function may be partly mediated by the WMHs.
Highlights
Plasma placental growth factor (PlGF) showed high diagnostic value for subcortical ischemic vascular dementia.
Plasma PlGF showed significantly negative correlation with cognition.
White matter hyperintensities mediated the relationship between plasma PlGF and cognition.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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