全皮肤放射治疗与低剂量螺旋断层治疗一例蕈样真菌病。

IF 1.3
Journal of cancer research and therapeutics Pub Date : 2025-04-01 Epub Date: 2024-01-22 DOI:10.4103/jcrt.jcrt_83_23
Atsuto Katano, Hideomi Yamashita
{"title":"全皮肤放射治疗与低剂量螺旋断层治疗一例蕈样真菌病。","authors":"Atsuto Katano, Hideomi Yamashita","doi":"10.4103/jcrt.jcrt_83_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Total body skin irradiation with electron beams has been used for patients with mycosis fungoides (MF). Recently, helical tomotherapy was considered available for total body irradiation, although severe myelosuppression was frequently observed as an adverse event. We report the first case of low-dose helical tomotherapy in a patient with MF. An 87-year-old Asian male with an 18-year medical history of MF was referred to our department due to a rapidly growing skin lesion during systemic therapy. He decided to undergo low-dose total skin radiotherapy with helical tomotherapy. The total skin was treated by dividing into three parts (trunk, head, and lower extremities). Each part was treated with helical radiotherapy consisting of 10 Gy in 5 fractions, with the administration of 5 fractions per week. Once the skin lesion clearly disappeared after total skin radiotherapy, recurrence was detected in the lower abdominal wall in the radiation-treated field. Insufficient doses of radiation therapy cause early relapse. There is still no optimized dose for total skin irradiation in helical tomotherapy. Further radiation therapy dose trials are required to optimize the treatment schedule.</p>","PeriodicalId":94070,"journal":{"name":"Journal of cancer research and therapeutics","volume":"21 3","pages":"712-715"},"PeriodicalIF":1.3000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Total skin radiation therapy with low-dose helical tomotherapy for a patient with mycosis fungoides.\",\"authors\":\"Atsuto Katano, Hideomi Yamashita\",\"doi\":\"10.4103/jcrt.jcrt_83_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Abstract: </strong>Total body skin irradiation with electron beams has been used for patients with mycosis fungoides (MF). Recently, helical tomotherapy was considered available for total body irradiation, although severe myelosuppression was frequently observed as an adverse event. We report the first case of low-dose helical tomotherapy in a patient with MF. An 87-year-old Asian male with an 18-year medical history of MF was referred to our department due to a rapidly growing skin lesion during systemic therapy. He decided to undergo low-dose total skin radiotherapy with helical tomotherapy. The total skin was treated by dividing into three parts (trunk, head, and lower extremities). Each part was treated with helical radiotherapy consisting of 10 Gy in 5 fractions, with the administration of 5 fractions per week. Once the skin lesion clearly disappeared after total skin radiotherapy, recurrence was detected in the lower abdominal wall in the radiation-treated field. Insufficient doses of radiation therapy cause early relapse. There is still no optimized dose for total skin irradiation in helical tomotherapy. Further radiation therapy dose trials are required to optimize the treatment schedule.</p>\",\"PeriodicalId\":94070,\"journal\":{\"name\":\"Journal of cancer research and therapeutics\",\"volume\":\"21 3\",\"pages\":\"712-715\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cancer research and therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jcrt.jcrt_83_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cancer research and therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jcrt.jcrt_83_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/22 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

摘要:应用电子束全身皮肤照射治疗蕈样真菌病(mycosis fungoides, MF)。最近,螺旋断层治疗被认为可用于全身照射,尽管严重的骨髓抑制经常被观察到作为不良事件。我们报告第一例低剂量螺旋断层治疗的病人与MF。一位87岁的亚洲男性,有18年的MF病史,因全身治疗期间皮肤病变迅速增长而转介到我科。他决定接受低剂量全皮肤放射治疗和螺旋断层治疗。整个皮肤分为三个部分(躯干、头部和下肢)进行治疗。每部分采用螺旋放射治疗,放射剂量为10 Gy,分5次,每周5次给药。全皮肤放射治疗后,一旦皮肤病变明显消失,则在放射治疗野的下腹壁发现复发。放射治疗剂量不足会导致早期复发。螺旋断层治疗中全皮肤照射的最佳剂量仍未确定。需要进一步的放射治疗剂量试验来优化治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Total skin radiation therapy with low-dose helical tomotherapy for a patient with mycosis fungoides.

Abstract: Total body skin irradiation with electron beams has been used for patients with mycosis fungoides (MF). Recently, helical tomotherapy was considered available for total body irradiation, although severe myelosuppression was frequently observed as an adverse event. We report the first case of low-dose helical tomotherapy in a patient with MF. An 87-year-old Asian male with an 18-year medical history of MF was referred to our department due to a rapidly growing skin lesion during systemic therapy. He decided to undergo low-dose total skin radiotherapy with helical tomotherapy. The total skin was treated by dividing into three parts (trunk, head, and lower extremities). Each part was treated with helical radiotherapy consisting of 10 Gy in 5 fractions, with the administration of 5 fractions per week. Once the skin lesion clearly disappeared after total skin radiotherapy, recurrence was detected in the lower abdominal wall in the radiation-treated field. Insufficient doses of radiation therapy cause early relapse. There is still no optimized dose for total skin irradiation in helical tomotherapy. Further radiation therapy dose trials are required to optimize the treatment schedule.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信