海马旁皮层7-特斯拉超高场MRI揭示了重性抑郁症和神经质人格特征的共同神经生物学机制的证据。

IF 5.8 1区 医学 Q1 PSYCHIATRY
Dominik Nießen, Ravichandran Rajkumar, Dilsa Cemre Akkoc Altinok, Gereon Johannes Schnellbächer, Shukti Ramkiran, Jana Hagen, Nadim Jon Shah, Tanja Veselinović, Irene Neuner
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引用次数: 0

摘要

海马旁皮层(PHC)是内侧颞叶(MTL)内一个高度互联的区域,对记忆、情感和认知至关重要。根据抑郁症的认知模型,这些过程中的功能障碍构成了重度抑郁症(MDD)的病理生理基础。研究表明,人的个性,特别是神经质,在重度抑郁症的发展和疾病进展中起着重要作用。此外,广泛的神经影像学证据表明,神经质和抑郁症具有重叠的结构和功能相关性,可能包括PHC。在匹配的86名成人样本中(43名重度抑郁症患者,43名对照参与者,平均年龄31.4岁,年龄范围18-61岁,40名女性),使用7 T超高场强的结构MRI测量PHC厚度,并与NEO-FFI量表测量的神经质水平进行比较。重度抑郁症患者的左半球PHC厚度明显低于健康对照组(pfdr = 0.002, η2 = 0.119)。此外,线性回归分析显示神经过敏与两半球PHC厚度之间存在显著相关性(L: pfdr = 0.012, β = -0.414;R: pfdr = 0.008, β = -0.512),高度神经质的个体表现出皮层厚度减少。这些发现表明,与神经质相结合,PHC厚度可以作为抑郁症的潜在生物标志物。我们的研究结果强调了多模式评估在重度抑郁症中的重要性,这可能有助于个性化临床决策的基础,并为精确精神病学铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
7-Tesla ultra-high field MRI of the parahippocampal cortex reveals evidence of common neurobiological mechanisms of major depressive disorder and neurotic personality traits.

The parahippocampal cortex (PHC) is a highly interconnected region within the medial temporal lobe (MTL) and is essential in memory, emotion and cognition. According to the cognitive model of depression, dysfunctions in these processes constitute the pathophysiological foundation of major depressive disorder (MDD). Research suggests that human personality, and neuroticism in particular, plays an important role in the development and disease progression of MDD. Furthermore, extensive neuroimaging evidence indicates that neuroticism and depression share overlapping structural and functional correlates, potentially including the PHC. In a matched sample of 86 adults (43 MDD patients, 43 control participants, mean age 31.4 years, range 18-61 years, 40 female), PHC thickness was measured using structural MRI at an ultra-high field strength of 7 T and compared to the level of neuroticism as measured by the NEO-FFI scale. MDD patients exhibited significantly lower left hemispheric PHC thickness compared to healthy controls (pfdr = 0.002, η2 = 0.119). Additionally, linear regression analysis revealed a significant association between neuroticism and PHC thickness within both hemispheres (L: pfdr = 0.012, β = -0.414; R: pfdr = 0.008, β = -0.512), with highly neurotic individuals displaying reduced cortical thickness. These findings suggest that, in combination with neuroticism, PHC thickness could serve as a potential biomarker of depression. Our results underscore the importance of multimodal assessments in MDD, potentially contributing to the foundation of individualised clinical decision-making and paving the way towards precision psychiatry.

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来源期刊
CiteScore
11.50
自引率
2.90%
发文量
484
审稿时长
23 weeks
期刊介绍: Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.
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