Dominik Nießen, Ravichandran Rajkumar, Dilsa Cemre Akkoc Altinok, Gereon Johannes Schnellbächer, Shukti Ramkiran, Jana Hagen, Nadim Jon Shah, Tanja Veselinović, Irene Neuner
{"title":"海马旁皮层7-特斯拉超高场MRI揭示了重性抑郁症和神经质人格特征的共同神经生物学机制的证据。","authors":"Dominik Nießen, Ravichandran Rajkumar, Dilsa Cemre Akkoc Altinok, Gereon Johannes Schnellbächer, Shukti Ramkiran, Jana Hagen, Nadim Jon Shah, Tanja Veselinović, Irene Neuner","doi":"10.1038/s41398-025-03435-y","DOIUrl":null,"url":null,"abstract":"<p><p>The parahippocampal cortex (PHC) is a highly interconnected region within the medial temporal lobe (MTL) and is essential in memory, emotion and cognition. According to the cognitive model of depression, dysfunctions in these processes constitute the pathophysiological foundation of major depressive disorder (MDD). Research suggests that human personality, and neuroticism in particular, plays an important role in the development and disease progression of MDD. Furthermore, extensive neuroimaging evidence indicates that neuroticism and depression share overlapping structural and functional correlates, potentially including the PHC. In a matched sample of 86 adults (43 MDD patients, 43 control participants, mean age 31.4 years, range 18-61 years, 40 female), PHC thickness was measured using structural MRI at an ultra-high field strength of 7 T and compared to the level of neuroticism as measured by the NEO-FFI scale. MDD patients exhibited significantly lower left hemispheric PHC thickness compared to healthy controls (p<sub>fdr</sub> = 0.002, η<sup>2</sup> = 0.119). Additionally, linear regression analysis revealed a significant association between neuroticism and PHC thickness within both hemispheres (L: p<sub>fdr</sub> = 0.012, β = -0.414; R: p<sub>fdr</sub> = 0.008, β = -0.512), with highly neurotic individuals displaying reduced cortical thickness. These findings suggest that, in combination with neuroticism, PHC thickness could serve as a potential biomarker of depression. Our results underscore the importance of multimodal assessments in MDD, potentially contributing to the foundation of individualised clinical decision-making and paving the way towards precision psychiatry.</p>","PeriodicalId":23278,"journal":{"name":"Translational Psychiatry","volume":"15 1","pages":"227"},"PeriodicalIF":5.8000,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228691/pdf/","citationCount":"0","resultStr":"{\"title\":\"7-Tesla ultra-high field MRI of the parahippocampal cortex reveals evidence of common neurobiological mechanisms of major depressive disorder and neurotic personality traits.\",\"authors\":\"Dominik Nießen, Ravichandran Rajkumar, Dilsa Cemre Akkoc Altinok, Gereon Johannes Schnellbächer, Shukti Ramkiran, Jana Hagen, Nadim Jon Shah, Tanja Veselinović, Irene Neuner\",\"doi\":\"10.1038/s41398-025-03435-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The parahippocampal cortex (PHC) is a highly interconnected region within the medial temporal lobe (MTL) and is essential in memory, emotion and cognition. According to the cognitive model of depression, dysfunctions in these processes constitute the pathophysiological foundation of major depressive disorder (MDD). Research suggests that human personality, and neuroticism in particular, plays an important role in the development and disease progression of MDD. Furthermore, extensive neuroimaging evidence indicates that neuroticism and depression share overlapping structural and functional correlates, potentially including the PHC. In a matched sample of 86 adults (43 MDD patients, 43 control participants, mean age 31.4 years, range 18-61 years, 40 female), PHC thickness was measured using structural MRI at an ultra-high field strength of 7 T and compared to the level of neuroticism as measured by the NEO-FFI scale. MDD patients exhibited significantly lower left hemispheric PHC thickness compared to healthy controls (p<sub>fdr</sub> = 0.002, η<sup>2</sup> = 0.119). Additionally, linear regression analysis revealed a significant association between neuroticism and PHC thickness within both hemispheres (L: p<sub>fdr</sub> = 0.012, β = -0.414; R: p<sub>fdr</sub> = 0.008, β = -0.512), with highly neurotic individuals displaying reduced cortical thickness. These findings suggest that, in combination with neuroticism, PHC thickness could serve as a potential biomarker of depression. Our results underscore the importance of multimodal assessments in MDD, potentially contributing to the foundation of individualised clinical decision-making and paving the way towards precision psychiatry.</p>\",\"PeriodicalId\":23278,\"journal\":{\"name\":\"Translational Psychiatry\",\"volume\":\"15 1\",\"pages\":\"227\"},\"PeriodicalIF\":5.8000,\"publicationDate\":\"2025-07-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228691/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41398-025-03435-y\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41398-025-03435-y","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
7-Tesla ultra-high field MRI of the parahippocampal cortex reveals evidence of common neurobiological mechanisms of major depressive disorder and neurotic personality traits.
The parahippocampal cortex (PHC) is a highly interconnected region within the medial temporal lobe (MTL) and is essential in memory, emotion and cognition. According to the cognitive model of depression, dysfunctions in these processes constitute the pathophysiological foundation of major depressive disorder (MDD). Research suggests that human personality, and neuroticism in particular, plays an important role in the development and disease progression of MDD. Furthermore, extensive neuroimaging evidence indicates that neuroticism and depression share overlapping structural and functional correlates, potentially including the PHC. In a matched sample of 86 adults (43 MDD patients, 43 control participants, mean age 31.4 years, range 18-61 years, 40 female), PHC thickness was measured using structural MRI at an ultra-high field strength of 7 T and compared to the level of neuroticism as measured by the NEO-FFI scale. MDD patients exhibited significantly lower left hemispheric PHC thickness compared to healthy controls (pfdr = 0.002, η2 = 0.119). Additionally, linear regression analysis revealed a significant association between neuroticism and PHC thickness within both hemispheres (L: pfdr = 0.012, β = -0.414; R: pfdr = 0.008, β = -0.512), with highly neurotic individuals displaying reduced cortical thickness. These findings suggest that, in combination with neuroticism, PHC thickness could serve as a potential biomarker of depression. Our results underscore the importance of multimodal assessments in MDD, potentially contributing to the foundation of individualised clinical decision-making and paving the way towards precision psychiatry.
期刊介绍:
Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod''s discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.