{"title":"急性呼吸窘迫综合征患者肺超声评分与死亡风险的相关性：一项荟萃分析。","authors":"Shisu Deng, Xing Liu, Yaxi Zhang, Yanqiong Tang, Jinquan Gao","doi":"10.1080/17520363.2025.2529770","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To clarify the relationship of lung ultrasound score (LUS) with the risk of mortality in patients with acute respiratory distress syndrome (ARDS).</p><p><strong>Methods: </strong>Several electronic databases were searched up to 14 October 2024. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined to assess the relationship between LUS and mortality in ARDS patients. Subgroup analysis stratified by the age and grouping method by LUS were further performed. Sensitivity analysis was performed to assess the stability of pooled results and Begg's funnel plot and Egger's test were applied to detect publication bias.</p><p><strong>Results: </strong>Sixteen studies with 1762 patients were included. Overall pooled results demonstrated that elevated LUS was significantly related to increased risk of mortality among ARDS patients (OR = 2.29, 95% CI: 1.45-3.63, P < 0.001). Besides, subgroup analysis stratified by the age (adult: OR = 2.01, <i>p</i> = 0.004; child: OR = 15.29, P < 0.001) and grouping method by LUS (dichotomous: OR = 5.60, <i>p</i> = 0.001; continuous: OR = 1.65, P < 0.001) revealed similar results. Sensitivity analysis indicated that pooled results were stable and Begg's funnel plot and Egger's test (<i>p</i> = 0.946) manifested that no significant publication bias was observed.</p><p><strong>Conclusion: </strong>Our meta-analysis indicates that a higher LUS is significantly associated with increased risk of mortality in ARDS patients.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"629-635"},"PeriodicalIF":1.9000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258206/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between lung ultrasound score and risk of mortality among acute respiratory distress syndrome patients: a meta-analysis.\",\"authors\":\"Shisu Deng, Xing Liu, Yaxi Zhang, Yanqiong Tang, Jinquan Gao\",\"doi\":\"10.1080/17520363.2025.2529770\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To clarify the relationship of lung ultrasound score (LUS) with the risk of mortality in patients with acute respiratory distress syndrome (ARDS).</p><p><strong>Methods: </strong>Several electronic databases were searched up to 14 October 2024. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined to assess the relationship between LUS and mortality in ARDS patients. Subgroup analysis stratified by the age and grouping method by LUS were further performed. Sensitivity analysis was performed to assess the stability of pooled results and Begg's funnel plot and Egger's test were applied to detect publication bias.</p><p><strong>Results: </strong>Sixteen studies with 1762 patients were included. Overall pooled results demonstrated that elevated LUS was significantly related to increased risk of mortality among ARDS patients (OR = 2.29, 95% CI: 1.45-3.63, P < 0.001). Besides, subgroup analysis stratified by the age (adult: OR = 2.01, <i>p</i> = 0.004; child: OR = 15.29, P < 0.001) and grouping method by LUS (dichotomous: OR = 5.60, <i>p</i> = 0.001; continuous: OR = 1.65, P < 0.001) revealed similar results. Sensitivity analysis indicated that pooled results were stable and Begg's funnel plot and Egger's test (<i>p</i> = 0.946) manifested that no significant publication bias was observed.</p><p><strong>Conclusion: </strong>Our meta-analysis indicates that a higher LUS is significantly associated with increased risk of mortality in ARDS patients.</p>\",\"PeriodicalId\":9182,\"journal\":{\"name\":\"Biomarkers in medicine\",\"volume\":\" \",\"pages\":\"629-635\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258206/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomarkers in medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/17520363.2025.2529770\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomarkers in medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17520363.2025.2529770","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/4 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨急性呼吸窘迫综合征（ARDS）患者肺超声评分（LUS）与死亡风险的关系。方法：检索截至2024年10月14日的多个电子数据库。结合优势比（ORs）和95%置信区间（CIs）来评估ARDS患者LUS与死亡率之间的关系。进一步进行年龄分层亚组分析和LUS分组法。采用敏感性分析评估合并结果的稳定性，采用Begg’s漏斗图和Egger’s检验检测发表偏倚。结果：纳入16项研究，1762例患者。总体汇总结果显示，LUS升高与ARDS患者死亡风险增加显著相关(OR = 2.29, 95% CI: 1.45-3.63, P = 0.004；儿童：OR = 15.29, P P = 0.001；连续：OR = 1.65, P = 0.946)表明未观察到显著的发表偏倚。结论：我们的荟萃分析表明，较高的LUS与ARDS患者死亡风险增加显著相关。
Association between lung ultrasound score and risk of mortality among acute respiratory distress syndrome patients: a meta-analysis.
Purpose: To clarify the relationship of lung ultrasound score (LUS) with the risk of mortality in patients with acute respiratory distress syndrome (ARDS).
Methods: Several electronic databases were searched up to 14 October 2024. Odds ratios (ORs) and 95% confidence intervals (CIs) were combined to assess the relationship between LUS and mortality in ARDS patients. Subgroup analysis stratified by the age and grouping method by LUS were further performed. Sensitivity analysis was performed to assess the stability of pooled results and Begg's funnel plot and Egger's test were applied to detect publication bias.
Results: Sixteen studies with 1762 patients were included. Overall pooled results demonstrated that elevated LUS was significantly related to increased risk of mortality among ARDS patients (OR = 2.29, 95% CI: 1.45-3.63, P < 0.001). Besides, subgroup analysis stratified by the age (adult: OR = 2.01, p = 0.004; child: OR = 15.29, P < 0.001) and grouping method by LUS (dichotomous: OR = 5.60, p = 0.001; continuous: OR = 1.65, P < 0.001) revealed similar results. Sensitivity analysis indicated that pooled results were stable and Begg's funnel plot and Egger's test (p = 0.946) manifested that no significant publication bias was observed.
Conclusion: Our meta-analysis indicates that a higher LUS is significantly associated with increased risk of mortality in ARDS patients.
期刊介绍：
Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory.
Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice.
As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications.
Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest.
Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.
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