Long-term outcome of Coats' disease: Implications for the classification of foveal vascular pathologies.

Purpose: To investigate the long-term outcome in patients with Coats' disease regarding initial stages.

Methods: Within a retrospective, clinical, single centre study, patients with diagnosed Coats' disease treated from 1992 to 2019 (minimum follow-up of 12 months) were investigated. A total of, 75 out of 123 patients met the inclusion criteria.

Results: A total of, 77 eyes of 75 patients (80.5% male, 17.8 ± 18.6 years, median 10 years) were analysed. Mean follow-up time was 7.2 ± 5.5 years (range 1.1-21.1 years, median 6.3 years). Initial and final visual acuity was lower the higher the disease stage was. The need for surgical interventions was higher in more advanced stages. Notably, within stage 2B, significant differences in final visual acuity were observed depending on the presence of foveal exudation only (0.20 ± 0.29 logMAR) as compared to eyes with foveal vascular abnormalities (1.20 ± 0.55 logMAR, p < 0.001).

Conclusion: Based on our analyses, it is suggested to amend the well-defined and established classification system according to Shields by sub-dividing stage 2B (telangiectasia and exudation with foveal exudation) into 2B1 (telangiectasia and exudation with foveal exudation) and 2B2 (telangiectasia and exudation with foveal exudation and foveal Coats' typical vascular abnormalities), since both subgroups significantly differ with respect to prognosis of visual acuity.