光动力疗法治疗面部审美敏感区域基底细胞癌的疗效和美学效果:一个病例系列研究。

Xu Ji, Li Ma, Yu Xin Ding, Jin Chi Zhang, Ming Kai Ji
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引用次数: 0

摘要

背景:手术切除美观面部区域(如鼻、眼周)的基底细胞癌(BCC)有毁容疤痕和功能缺陷的风险,特别是对于有手术禁忌症或广泛病变且肿瘤完全清除具有挑战性的老年患者。对于这一人群,传统的手术方式往往会带来很大的围手术期负担。目的:评价光动力疗法(PDT)作为一种非手术治疗面部关键部位BCC的临床疗效和美学效果。方法:本病例系列分析了3例组织学证实的BCC(结节性、溃疡性和浸润性亚型),累及鼻腔、眼周和脸颊区域。所有受试者均行清创预处理后光动力治疗(PDT)。结果:经过3个月的临床及皮肤镜检查,所有病例均获得肿瘤完全清除。溃疡病变表现为完整的上皮化,保留鼻翼结构、眼睑边缘完整和自然的脸颊轮廓。短暂性红斑自行消退,无瘢痕或色素沉着。1年随访期间无复发。结论:ALA-PDT在保留关键面部解剖结构的同时实现了精确的肿瘤根除,可作为老年人群解剖结构复杂的bcc的可行一线选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy and Aesthetic Outcomes of Photodynamic Therapy for Basal Cell Carcinoma in Aesthetic-Sensitive Facial Regions: A Case Series Study.

Background: Surgical excision of basal cell carcinoma (BCC) in aesthetic facial regions (e.g., nasal, periocular) risks disfiguring scars and functional deficits, particularly for elderly patients with surgical contraindications or extensive lesions where complete tumor clearance proves challenging. Conventional approaches often carry significant perioperative burdens for this demographic.

Objective: To evaluate the clinical efficacy and aesthetic outcomes of photodynamic therapy (PDT) as a non-surgical alternative for BCC in cosmetically critical facial areas.

Methods: This case series analyzed three patients with histologically confirmed BCC (nodular, ulcerative, and infiltrative subtypes) involving nasal, periocular, and cheek regions. All subjects underwent debridement pretreatment followed by photodynamic therapy (PDT).

Results: Complete tumor clearance was achieved in all cases, confirmed by 3-month clinical and dermoscopic evaluation. Ulcerated lesions demonstrated full epithelialization with preserved nasal alar architecture, eyelid margin integrity, and natural cheek contour. Transient erythema resolved spontaneously without scarring or dyspigmentation. No recurrences were observed during the 1-year follow-up period.

Conclusion: ALA-PDT achieves precise tumor eradication while preserving critical facial anatomy, serving as a viable first-line option for anatomically complex BCCs in elderly populations.

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