circRNA作为结直肠癌潜在靶点的生物学功能和作用机制。

Yuzhi Gao, Chang Li, Tuo Ji, Kun Yu, Xuzhu Gao
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引用次数: 0

摘要

结直肠癌(CRC)是世界上最常见的恶性肿瘤之一。其发病率持续上升,晚期的治疗选择仍然有限。近年来,环状rna (circRNAs),一类特殊的非编码rna,在癌症治疗中显示出潜在的应用前景。CircRNAs具有高度的稳定性和组织特异性,它们通过多种机制在肿瘤的发生和发展中发挥作用,如作为microRNA (miRNA)海绵、与蛋白质相互作用、调节转录、参与信号转导等。在CRC中,特异性环状rna可以调节肿瘤微环境中的基因表达,从而影响肿瘤细胞行为、血管生成、免疫逃避和代谢重编程。此外,环状rna有望成为CRC的潜在诊断和预后生物标志物以及治疗靶点。尽管越来越多的原始研究揭示了环状rna在结直肠癌中的多种功能,但综合这些发现并将其与临床相关性联系起来的综合综述仍然很少。这篇叙述性综述探讨了CRC中circRNA研究的最新进展,并讨论了它们作为诊断和预后生物标志物、治疗剂和药物靶点的临床潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The biological function and mechanism of action of circRNA as a potential target in colorectal cancer.

Colorectal cancer (CRC) is one of the most common malignancies worldwide. Its incidence continues to rise, and treatment options for advanced stages are still limited. In recent years, circular RNAs (circRNAs), a special class of non-coding RNAs, have demonstrated potential applications in cancer therapy. CircRNAs exhibit high stability and tissue specificity, and they play roles in tumorigenesis and progression through multiple mechanisms, such as acting as microRNA (miRNA) sponges, interacting with proteins, modulating transcription, and participating in signal transduction. In CRC specific circRNAs can regulate gene expression within the tumor microenvironment, thereby influencing tumor cell behavior, angiogenesis, immune evasion, and metabolic reprogramming. Moreover, circRNAs hold promise as potential diagnostic and prognostic biomarkers, as well as therapeutic targets for CRC. Although an increasing number of original studies have revealed the diverse functions of circRNAs in CRC, comprehensive reviews that synthesize these findings and relate them to clinical relevance remain scarce. This narrative review explores the latest advances in circRNA research in CRC and discusses their clinical potential as diagnostic and prognostic biomarkers, therapeutic agents, and drug targets.

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