Evaluation of the effectiveness of preoperative 3D reconstruction combined with intraoperative augmented reality fluorescence guidance system in laparoscopic liver surgery: a retrospective cohort study.

Objective: To evaluate the effectiveness of preoperative 3D reconstruction combined with intraoperative augmented reality fluorescence guidance system in laparoscopic liver surgery by establishing a retrospective cohort study.

Methods: A retrospective cohort study was conducted from March 2023 to December 2024, with patients' data from the medical record system. Patients were divided into two groups according to their surgical protocols: 46 cases in the control group (conventional laparoscopic liver surgery) and 50 cases in the observation group (preoperative 3D reconstruction combined with intraoperative augmented-reality fluorescence guiding system in laparoscopic liver surgery). We compared perioperative indexes (operation time, intraoperative bleeding, time to first flatus, drainage tube removal time, hospitalization time), preoperative and postoperative liver function indexes [alanine aminotransferase (ALT), albumin (ALB), total bilirubin (TBIL)], stress indexes [angiotensin II (AT II), norepinephrine (NE), epinephrine (AD)], and complication rates between the two groups.

Results: The operation time of patients in the observation group was shorter than that of patients in the control group (110.75 ± 20.56 vs. 122.35 ± 20.48 min, 95% CI of difference: 2.52-20.68 min, p = 0.013), and the amount of intraoperative bleeding was less (300.80 ± 32.70 vs. 320.76 ± 35.84 mL, 95% CI of difference: 7.62-32.30 mL, p = 0.002). There was no statistically significant difference in the comparison of time to first flatus, drain removal time, hospitalization time and complication rate between the two groups (p > 0.05). Preoperatively, the comparison of ALT, ALB, TBIL, AT II, NE, AD levels of patients in the two groups were not statistically significant (p > 0.05); postoperatively, the AT II, NE, AD levels of patients in the observation group were lower than those of patients in the control group, with statistically significant differences (p < 0.001), while the differences in ALT, ALB, TBIL levels were not statistically significant (p > 0.05). For malignant cases, the R0 resection rate was similar between groups (92.3% vs. 89.5%, p = 0.724).

Conclusion: Preoperative 3D reconstruction combined with intraoperative augmented reality fluorescence guidance system is potentially beneficial for laparoscopic liver surgery, which can modestly shorten the operation time, reduce intraoperative bleeding, and alleviate postoperative stress reactions.