水霉素A治疗伯氏疏螺旋体感染的白色过omyscus leucopus显示了作为库靶向抗生素的潜力。

IF 4.5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-07-04 DOI:10.1093/infdis/jiaf363

Stephanie S You, Muskan Shrestha, Jeffrey S Bourgeois, Luke H Clendenen, Nadja Leimer, Kim Lewis, Sam R Telford, Linden T Hu

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引用次数: 0

摘要

莱姆病螺旋体在传播到人类群体之前一直保存在自然水库中。针对这些宿主接种疫苗或使用抗生素可以影响伯氏疏螺旋体的人畜共患病循环，并降低人类莱姆病的风险。在这项工作中，我们报告了窄谱抗生素湿霉素A足以破坏伯氏疏螺旋体从美国东部主要水库，白斑Peromyscus leucopus向蜱虫的传播。此外，含湿霉素a的饵料可清除白棘球绦虫中的伯氏疏螺旋体。这些研究为使用湿霉素A作为库靶向抗生素在野外根除伯氏疏螺旋体奠定了基础。

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Hygromycin A treatment of Borrelia burgdorferi-infected Peromyscus leucopus suggests potential as a reservoir-targeted antibiotic.

Lyme disease spirochetes are maintained in natural reservoirs before spilling over into human populations. Targeting these reservoirs with vaccinations or antibiotics could impact the B. burgdorferi enzootic cycle and reduce the risk of human Lyme disease. In this work we report that the narrow spectrum antibiotic hygromycin A is sufficient to disrupt B. burgdorferi transmission from the main eastern U.S. reservoir, Peromyscus leucopus, to ticks. Additionally, hygromycin A-containing baits can clear B. burgdorferi from P. leucopus. These studies lay the foundation for the use of hygromycin A as a reservoir-targeted antibiotic to eradicate B. burgdorferi in the wild.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.