{"title":"补充脱氢表雄酮对绝经后妇女睾酮和雌二醇水平的影响:一项评估剂量和持续时间效应的随机对照试验的荟萃分析","authors":"ShuYun He, Kunna Lu, Lianying Zhang, Hanwen Cao, Xinyuan Tang, Xinhuan Zhang","doi":"10.1186/s13098-025-01770-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aim: </strong>The effects of dehydroepiandrosterone (DHEA) supplementation on testosterone and estradiol concentrations in postmenopausal women have produced conflicting results. This meta-analysis of randomized controlled trials aimed to evaluate the impact of DHEA supplementation on serum testosterone and estradiol levels and to provide evidence regarding the optimal dosage and duration of supplementation.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed/Medline, Embase, Web of Science, and Scopus to identify relevant studies published before June 11, 2024. Data were analyzed using a random-effects model and presented as weighted mean differences (WMDs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The analysis included 21 studies, comprising 17 trial arms assessing estradiol and 20 assessing testosterone. DHEA supplementation significantly increased estradiol (WMD: 7.86 pg/mL; 95% CI 6.33-9.40; P ≤ 0.001) and testosterone levels (WMD: 24.31 ng/dL; 95% CI 15.22-33.40; P ≤ 0.001). Subgroup analyses showed greater increases in estradiol levels among studies using DHEA dosages ≥ 50 mg/day (WMD: 8.65 pg/mL) and those with participants aged ≥ 60 years (WMD: 8.92 pg/mL), although the differences were modest and 95% CIs overlapped. For testosterone, higher levels were observed with DHEA dosages ≥ 50 mg/day (WMD: 29.65 ng/dL).</p><p><strong>Conclusion: </strong>DHEA supplementation at doses ≥ 50 mg/day significantly increases testosterone levels in postmenopausal women. Moreover, in women aged ≥ 60 years, supplementation at the same dosage significantly elevates estradiol levels.</p>","PeriodicalId":11106,"journal":{"name":"Diabetology & Metabolic Syndrome","volume":"17 1","pages":"258"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of DHEA supplementation on testosterone and estradiol levels in postmenopausal women: a meta-analysis of randomized controlled trials assessing dose and duration effects.\",\"authors\":\"ShuYun He, Kunna Lu, Lianying Zhang, Hanwen Cao, Xinyuan Tang, Xinhuan Zhang\",\"doi\":\"10.1186/s13098-025-01770-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and aim: </strong>The effects of dehydroepiandrosterone (DHEA) supplementation on testosterone and estradiol concentrations in postmenopausal women have produced conflicting results. This meta-analysis of randomized controlled trials aimed to evaluate the impact of DHEA supplementation on serum testosterone and estradiol levels and to provide evidence regarding the optimal dosage and duration of supplementation.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed/Medline, Embase, Web of Science, and Scopus to identify relevant studies published before June 11, 2024. Data were analyzed using a random-effects model and presented as weighted mean differences (WMDs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The analysis included 21 studies, comprising 17 trial arms assessing estradiol and 20 assessing testosterone. DHEA supplementation significantly increased estradiol (WMD: 7.86 pg/mL; 95% CI 6.33-9.40; P ≤ 0.001) and testosterone levels (WMD: 24.31 ng/dL; 95% CI 15.22-33.40; P ≤ 0.001). Subgroup analyses showed greater increases in estradiol levels among studies using DHEA dosages ≥ 50 mg/day (WMD: 8.65 pg/mL) and those with participants aged ≥ 60 years (WMD: 8.92 pg/mL), although the differences were modest and 95% CIs overlapped. For testosterone, higher levels were observed with DHEA dosages ≥ 50 mg/day (WMD: 29.65 ng/dL).</p><p><strong>Conclusion: </strong>DHEA supplementation at doses ≥ 50 mg/day significantly increases testosterone levels in postmenopausal women. 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引用次数: 0
摘要
背景和目的:补充脱氢表雄酮(DHEA)对绝经后妇女睾酮和雌二醇浓度的影响产生了相互矛盾的结果。这项随机对照试验的荟萃分析旨在评估DHEA补充对血清睾酮和雌二醇水平的影响,并提供有关补充的最佳剂量和持续时间的证据。方法:综合检索PubMed/Medline、Embase、Web of Science、Scopus等数据库,检索2024年6月11日前发表的相关研究。数据采用随机效应模型进行分析,并以加权平均差(wmd)和95%置信区间(ci)表示。结果:该分析包括21项研究,其中17个试验组评估雌二醇,20个试验组评估睾酮。补充脱氢表雄酮显著增加雌二醇(WMD: 7.86 pg/mL;95% ci 6.33-9.40;P≤0.001)和睾酮水平(WMD: 24.31 ng/dL;95% ci 15.22-33.40;p≤0.001)。亚组分析显示,在DHEA剂量≥50 mg/天(WMD: 8.65 pg/mL)和参与者年龄≥60岁(WMD: 8.92 pg/mL)的研究中,雌二醇水平增加更大,尽管差异不大,95% ci重叠。对于睾酮,DHEA剂量≥50 mg/d (WMD: 29.65 ng/dL)时,睾酮水平较高。结论:补充DHEA剂量≥50mg /天可显著提高绝经后妇女的睾酮水平。此外,在年龄≥60岁的女性中,相同剂量的补充显著提高雌二醇水平。
Impact of DHEA supplementation on testosterone and estradiol levels in postmenopausal women: a meta-analysis of randomized controlled trials assessing dose and duration effects.
Background and aim: The effects of dehydroepiandrosterone (DHEA) supplementation on testosterone and estradiol concentrations in postmenopausal women have produced conflicting results. This meta-analysis of randomized controlled trials aimed to evaluate the impact of DHEA supplementation on serum testosterone and estradiol levels and to provide evidence regarding the optimal dosage and duration of supplementation.
Methods: A comprehensive literature search was conducted across PubMed/Medline, Embase, Web of Science, and Scopus to identify relevant studies published before June 11, 2024. Data were analyzed using a random-effects model and presented as weighted mean differences (WMDs) with 95% confidence intervals (CIs).
Results: The analysis included 21 studies, comprising 17 trial arms assessing estradiol and 20 assessing testosterone. DHEA supplementation significantly increased estradiol (WMD: 7.86 pg/mL; 95% CI 6.33-9.40; P ≤ 0.001) and testosterone levels (WMD: 24.31 ng/dL; 95% CI 15.22-33.40; P ≤ 0.001). Subgroup analyses showed greater increases in estradiol levels among studies using DHEA dosages ≥ 50 mg/day (WMD: 8.65 pg/mL) and those with participants aged ≥ 60 years (WMD: 8.92 pg/mL), although the differences were modest and 95% CIs overlapped. For testosterone, higher levels were observed with DHEA dosages ≥ 50 mg/day (WMD: 29.65 ng/dL).
Conclusion: DHEA supplementation at doses ≥ 50 mg/day significantly increases testosterone levels in postmenopausal women. Moreover, in women aged ≥ 60 years, supplementation at the same dosage significantly elevates estradiol levels.
期刊介绍:
Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome.
By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.