酵母中β-胡萝卜素及其衍生物的生物合成研究进展。

IF 9.7 1区 环境科学与生态学 Q1 AGRICULTURAL ENGINEERING
Tingan Zhou , Young-Kyoung Park , Rodrigo Ledesma-Amaro
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引用次数: 0

摘要

β-胡萝卜素及其衍生物在食品补充剂、保健品、药品、色素等方面的应用已引起人们极大的兴趣。由于其高价值,微生物可持续生产一直是一个热门的研究课题。传统的生产方法,如植物提取和化学合成,在可扩展性、成本和环境影响方面面临挑战。随着合成生物学的进步,以酵母为基础的生物合成已成为一种有前途的替代方法。本文综述了酵母代谢工程策略和发酵优化方法的最新进展,特别是酿酒酵母和解脂耶氏酵母,用于生产β-胡萝卜素及其衍生物。与以往的综述相反,本研究强调了结构相关衍生物的共同生物合成逻辑,并将其分为两大类:叶黄素(角黄素、玉米黄素、虾青素和紫黄素)和类胡萝卜素(胡萝卜素、视黄醇、β-离子酮、β-环柠檬醛和独角果酸内酯)。突出了代表性案例和可转移的工程/发酵策略。全面比较了酵母作为生产宿主的优势和局限性,并讨论了提高产量的潜在策略。未来的工作将集中在扩大不同酵母宿主的产品多样性和提高生物合成效率,以实现更可持续的生产。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in the biosynthesis of β-carotene and its derivatives in yeast
β-Carotene and its derivatives have been gaining huge interest due to its applications as food supplements, nutraceuticals, pharmaceuticals, pigments, etc. Owing to their high values, sustainable microbial production has been a heated research topic. Traditional production methods, such as plant extraction and chemical synthesis, face challenges in scalability, cost, and environmental impact. With advances in synthetic biology, yeast-based biosynthesis has emerged as a promising alternative. This review provides a comprehensive summary of recent progress in the metabolic engineering strategies and fermentation optimization approaches of yeast, particularly Saccharomyces cerevisiae and Yarrowia lipolytica, for the production of β-carotene and its derivatives. In contrast to previous reviews, this work emphasizes the shared biosynthetic logic underlying structurally related derivatives, classifying them into two major groups: xanthophylls (canthaxanthin, zeaxanthin, astaxanthin, and violaxanthin) and apocarotenoids (crocetin, retinol, β-ionone, β-cyclocitral, and strigolactones). Representative cases and transferable engineering/fermentation strategies are highlighted. Advantages and limitations of yeast species as production hosts are thoroughly compared, and potential strategies to improve the production are discussed. Future work may focus on broadening product diversity in different yeast hosts and enhancing biosynthetic efficiency for a more sustainable production.
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来源期刊
Bioresource Technology
Bioresource Technology 工程技术-能源与燃料
CiteScore
20.80
自引率
19.30%
发文量
2013
审稿时长
12 days
期刊介绍: Bioresource Technology publishes original articles, review articles, case studies, and short communications covering the fundamentals, applications, and management of bioresource technology. The journal seeks to advance and disseminate knowledge across various areas related to biomass, biological waste treatment, bioenergy, biotransformations, bioresource systems analysis, and associated conversion or production technologies. Topics include: • Biofuels: liquid and gaseous biofuels production, modeling and economics • Bioprocesses and bioproducts: biocatalysis and fermentations • Biomass and feedstocks utilization: bioconversion of agro-industrial residues • Environmental protection: biological waste treatment • Thermochemical conversion of biomass: combustion, pyrolysis, gasification, catalysis.
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