觉醒障碍与睡眠相关性运动性癫痫是相互关联的。一些新观点

IF 2.7 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy Pub Date : 2025-06-05 DOI:10.1016/j.seizure.2025.06.002

Péter Halász , Anna Szűcs

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引用次数: 0

摘要

非快速眼动睡眠异常与睡眠相关的多动性癫痫在多个方面重叠。这两种情况的特点都是睡眠碎片化；共有症状特征；有家族和群体遗传关系；非快速眼动睡眠异常发作是由睡眠-觉醒分离引起的，也可能是SHE发作的特征。最重要的是，这两种情况与NREM睡眠的高稳态压力期有着非常相似的联系，这与睡眠微观结构密切相关，包括睡眠样微觉醒、循环交替模式A1的动力学和慢波双稳定性。虽然对癫痫和非癫痫两种情况的明确区分在理论上和实践上都是必不可少的；他们之间惊人的关系需要解释。

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Disorders of arousal and sleep-related hypermotor epilepsy are interrelated. Some new viewpoints

NREM parasomnias overlap with sleep-related hypermotor epilepsies in multiple ways. Both conditions are characterized by fragmented sleep; share symptomatic features; have family-, and population-genetic relationships; and NREM parasomnia-episodes are underlain by sleep-wake dissociation likely featuring SHE seizures as well. Most importantly, the two conditions have very similar links with NREM sleep’s high homeostatic pressure periods closely related to sleep microstructure including sleep-like micro-arousals, the dynamics of cyclic alternating pattern A1 and slow wave bistability. While the unquestionable distinction of the two conditions, epileptic and non-epileptic, is essential both theoretically and practically; their striking relationship calls for explanation.

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来源期刊

Seizure-European Journal of Epilepsy 医学-临床神经学

CiteScore

5.60

自引率

6.70%

发文量

231

审稿时长

34 days

期刊介绍： Seizure - European Journal of Epilepsy is an international journal owned by Epilepsy Action (the largest member led epilepsy organisation in the UK). It provides a forum for papers on all topics related to epilepsy and seizure disorders.