金属元素暴露和氧化应激在轻度认知障碍中的作用:来自上海老年队列的证据

IF 6.1 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Ying Qing , Jianheng Zheng , TianRan Tang , Yingyi Luo , Dan Han , Liqiang Wang , Yaxin Dong , Shuyu Yang , Jun Du , Yanfei Li
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引用次数: 0

摘要

本研究通过对上海地区老年人的横断面研究,探讨混合金属元素暴露与轻度认知障碍(MCI)的关系,以及氧化应激的中介作用。我们使用蒙特利尔认知评估(MoCA)量表评估MCI,并测量血浆中淀粉样蛋白β40 (Aβ40)、Aβ42、Aβ42/40、总tau (T-tau)和磷酸化tau (P-tau)蛋白的水平。采用Spearman相关分析、线性回归、加权分位数和(WQS)回归和分位数g-计算(qgcomp)模型评估金属元素与MCI之间的关系,并利用中介模型分析氧化应激的中介作用。结果显示,MCI组血镉(Cd)、铅(Pb)、铜(Cu)、锌(Zn)、硒(Se)水平与认知正常组有显著差异。MoCA评分与Cd、Pb、Cu水平呈负相关,与Zn、Se水平呈正相关。Aβ42和Aβ42/40与Cu呈负相关,与Zn、Se呈正相关。P-tau与汞(Hg)呈正相关。WQS指数与MoCA评分呈显著负相关,其中Cu贡献最大(84.0 %)。同时,Aβ42和Aβ42/40与WQS指数呈显著正相关,其中Se(34.0 %)和Zn(58.3 %)为主要贡献因子。Qgcomp模型还发现,混合暴露于金属元素与MoCA分数呈显著负相关,其中Cu的负权重最高(-0.601)。SOD部分介导了Cu、Zn、Se和WQS指数与Aβ42的相关性(中介率为14.3 ~ 27.8 %)。本研究为识别影响轻度认知障碍的因素和潜在机制提供了基于人群的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of metal element exposure and oxidative stress in mild cognitive impairment: Evidence from a Shanghai elderly cohort
This study, based on a cross-sectional study of elderly individuals in Shanghai, explored the associations between mixed metal element exposure and mild cognitive impairment (MCI), as well as the mediating role of oxidative stress. We assessed MCI using the Montreal Cognitive Assessment (MoCA) scale and measured plasma levels of amyloid β40 (Aβ40), Aβ42, Aβ42/40, total tau (T-tau) and phosphorylated tau (P-tau) proteins. Spearman’s correlation analysis, linear regression, weighted quantile sum (WQS) regression, and quantile g-computation (qgcomp) modeling were used to assess the associations between metal elements and MCI, and to analyze the mediating role of oxidative stress using mediation models. The results showed significant differences in blood cadmium (Cd), lead (Pb), copper (Cu), zinc (Zn), and selenium (Se) levels between the MCI group and the normal cognition group. MoCA scores were negatively correlated with Cd, Pb, and Cu levels, and positively correlated with Zn and Se levels. Aβ42 and Aβ42/40 were negatively correlated with Cu and positively correlated with Zn and Se. P-tau was positively correlated with mercury (Hg). The WQS index was significantly negatively correlated with the MoCA score, with Cu contributing the most (84.0 %). Meanwhile, Aβ42 and Aβ42/40 were significantly positively correlated with the WQS index, with Se (34.0 %) and Zn (58.3 %) being the main contributors. Qgcomp modeling also found that mixed exposure to metal elements was significantly negatively correlated with the MoCA score, with Cu given the highest negative weight (-0.601). SOD partially mediated the correlation of Cu, Zn, Se, and WQS index with Aβ42 (mediation ratio of 14.3–27.8 %). This study provides population-based evidence for identifying factors and potential mechanisms affecting MCI.
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来源期刊
CiteScore
12.10
自引率
5.90%
发文量
1234
审稿时长
88 days
期刊介绍: Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.
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