Sumayya Abdullahi, Idris N Abdullahi, Hafeez A Adekola, Nicholas Baamlong, Amos Dangana, Yahaya Usman, Abdurrahman E Ahmad, Sumaiya Salisu, Mukhtar M Abdulaziz
{"title":"尼日利亚Ahmadu Bello大学医护专业学生金黄色葡萄球菌鼻腔携带率及多种抗微生物药物耐药性指标","authors":"Sumayya Abdullahi, Idris N Abdullahi, Hafeez A Adekola, Nicholas Baamlong, Amos Dangana, Yahaya Usman, Abdurrahman E Ahmad, Sumaiya Salisu, Mukhtar M Abdulaziz","doi":"10.4102/ajlm.v14i1.2667","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Healthcare students could harbour multidrug-resistant (MDR) and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). There is a need to understand the extent and factors associated with nasal carriage of these strains.</p><p><strong>Objective: </strong>This study determined the frequency and risk of nasal <i>S. aureus,</i> and multiple antimicrobial resistance indices among students at Ahmadu Bello University, Zaria, Nigeria.</p><p><strong>Methods: </strong>This comparative cross-sectional study collected nasal samples from 02 January 2024 to 31 July 2024 from healthcare students at Ahmadu Bello University, Nigeria, which were processed for <i>S. aureus</i> identification. Antimicrobial resistance phenotype was determined by the disk diffusion method. Structured questionnaires were used to collect participants' sociodemographic and risk factor data.</p><p><strong>Results: </strong>A total of 251 students participated, including 126 (50.2%) men and 125 (49.8%) women (aged 17-44 years). The nasal carriage of <i>S. aureus</i> was 31.5% (79/251) and MRSA was 23.5% (59/251). Clinical-phase students had a higher frequency of nasal MRSA (25%) than preclinical-phase students (22.1%). <i>Staphylococcus aureus</i> resistance against non-beta-lactams was highest for tetracycline (49.4%) and ciprofloxacin (29.1%), with 39.2% (31/79) showing MDR. Medical and pharmacy students had statistically significant higher nasal carriage of MDR-<i>S. aureus</i> (<i>p</i> < 0.05). Students residing in households of 5-8 individuals had the highest nasal MDR-<i>S. aureus</i> carriage (<i>p</i> = 0.0044). <i>Staphylococcus aureus</i> isolates with multiple antimicrobial resistance indices of 0.2 (29.1%) and 0.3 (24%) were the most predominant.</p><p><strong>Conclusion: </strong>High levels of nasal MRSA and MDR-<i>S. aureus</i> were obtained from this study. The predominance of strains with high antimicrobial resistance indicates sources with high antibiotic use.</p><p><strong>What this study adds: </strong>To our knowledge, this is the first epidemiological study on the multiple antimicrobial resistance indices of nasal <i>S. aureus</i> in healthcare students in Africa. Moreover, this is the first report to categorises subgroup variation of nasal MDR-<i>S. aureus</i> carriage by the six major groups of healthcare students.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"14 1","pages":"2667"},"PeriodicalIF":1.0000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223919/pdf/","citationCount":"0","resultStr":"{\"title\":\"Nasal carriage rate and multiple antimicrobial resistance indices of <i>Staphylococcus aureus</i> among healthcare students at the Ahmadu Bello University, Nigeria.\",\"authors\":\"Sumayya Abdullahi, Idris N Abdullahi, Hafeez A Adekola, Nicholas Baamlong, Amos Dangana, Yahaya Usman, Abdurrahman E Ahmad, Sumaiya Salisu, Mukhtar M Abdulaziz\",\"doi\":\"10.4102/ajlm.v14i1.2667\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Healthcare students could harbour multidrug-resistant (MDR) and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). There is a need to understand the extent and factors associated with nasal carriage of these strains.</p><p><strong>Objective: </strong>This study determined the frequency and risk of nasal <i>S. aureus,</i> and multiple antimicrobial resistance indices among students at Ahmadu Bello University, Zaria, Nigeria.</p><p><strong>Methods: </strong>This comparative cross-sectional study collected nasal samples from 02 January 2024 to 31 July 2024 from healthcare students at Ahmadu Bello University, Nigeria, which were processed for <i>S. aureus</i> identification. Antimicrobial resistance phenotype was determined by the disk diffusion method. Structured questionnaires were used to collect participants' sociodemographic and risk factor data.</p><p><strong>Results: </strong>A total of 251 students participated, including 126 (50.2%) men and 125 (49.8%) women (aged 17-44 years). The nasal carriage of <i>S. aureus</i> was 31.5% (79/251) and MRSA was 23.5% (59/251). Clinical-phase students had a higher frequency of nasal MRSA (25%) than preclinical-phase students (22.1%). <i>Staphylococcus aureus</i> resistance against non-beta-lactams was highest for tetracycline (49.4%) and ciprofloxacin (29.1%), with 39.2% (31/79) showing MDR. Medical and pharmacy students had statistically significant higher nasal carriage of MDR-<i>S. aureus</i> (<i>p</i> < 0.05). Students residing in households of 5-8 individuals had the highest nasal MDR-<i>S. aureus</i> carriage (<i>p</i> = 0.0044). <i>Staphylococcus aureus</i> isolates with multiple antimicrobial resistance indices of 0.2 (29.1%) and 0.3 (24%) were the most predominant.</p><p><strong>Conclusion: </strong>High levels of nasal MRSA and MDR-<i>S. aureus</i> were obtained from this study. The predominance of strains with high antimicrobial resistance indicates sources with high antibiotic use.</p><p><strong>What this study adds: </strong>To our knowledge, this is the first epidemiological study on the multiple antimicrobial resistance indices of nasal <i>S. aureus</i> in healthcare students in Africa. Moreover, this is the first report to categorises subgroup variation of nasal MDR-<i>S. aureus</i> carriage by the six major groups of healthcare students.</p>\",\"PeriodicalId\":45412,\"journal\":{\"name\":\"African Journal of Laboratory Medicine\",\"volume\":\"14 1\",\"pages\":\"2667\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223919/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Journal of Laboratory Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4102/ajlm.v14i1.2667\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Journal of Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4102/ajlm.v14i1.2667","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Nasal carriage rate and multiple antimicrobial resistance indices of Staphylococcus aureus among healthcare students at the Ahmadu Bello University, Nigeria.
Background: Healthcare students could harbour multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA). There is a need to understand the extent and factors associated with nasal carriage of these strains.
Objective: This study determined the frequency and risk of nasal S. aureus, and multiple antimicrobial resistance indices among students at Ahmadu Bello University, Zaria, Nigeria.
Methods: This comparative cross-sectional study collected nasal samples from 02 January 2024 to 31 July 2024 from healthcare students at Ahmadu Bello University, Nigeria, which were processed for S. aureus identification. Antimicrobial resistance phenotype was determined by the disk diffusion method. Structured questionnaires were used to collect participants' sociodemographic and risk factor data.
Results: A total of 251 students participated, including 126 (50.2%) men and 125 (49.8%) women (aged 17-44 years). The nasal carriage of S. aureus was 31.5% (79/251) and MRSA was 23.5% (59/251). Clinical-phase students had a higher frequency of nasal MRSA (25%) than preclinical-phase students (22.1%). Staphylococcus aureus resistance against non-beta-lactams was highest for tetracycline (49.4%) and ciprofloxacin (29.1%), with 39.2% (31/79) showing MDR. Medical and pharmacy students had statistically significant higher nasal carriage of MDR-S. aureus (p < 0.05). Students residing in households of 5-8 individuals had the highest nasal MDR-S. aureus carriage (p = 0.0044). Staphylococcus aureus isolates with multiple antimicrobial resistance indices of 0.2 (29.1%) and 0.3 (24%) were the most predominant.
Conclusion: High levels of nasal MRSA and MDR-S. aureus were obtained from this study. The predominance of strains with high antimicrobial resistance indicates sources with high antibiotic use.
What this study adds: To our knowledge, this is the first epidemiological study on the multiple antimicrobial resistance indices of nasal S. aureus in healthcare students in Africa. Moreover, this is the first report to categorises subgroup variation of nasal MDR-S. aureus carriage by the six major groups of healthcare students.
期刊介绍：
The African Journal of Laboratory Medicine, the official journal of ASLM, focuses on the role of the laboratory and its professionals in the clinical and public healthcare sectors,and is specifically based on an African frame of reference. Emphasis is on all aspects that promote and contribute to the laboratory medicine practices of Africa. This includes, amongst others: laboratories, biomedical scientists and clinicians, medical community, public health officials and policy makers, laboratory systems and policies (translation of laboratory knowledge, practices and technologies in clinical care), interfaces of laboratory with medical science, laboratory-based epidemiology, laboratory investigations, evidence-based effectiveness in real world (actual) settings.
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