Deep Madkaiker, Shashank Ojha, Arunkumar N, Kalpesh Chawan
{"title":"在印度西部的一家三级肿瘤医院，储存前白细胞诱导对红细胞浓缩物和新一代白细胞过滤器性能的影响。","authors":"Deep Madkaiker, Shashank Ojha, Arunkumar N, Kalpesh Chawan","doi":"10.4102/ajlm.v14i1.2723","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Leukoreduction is a post-processing technique that reduces residual leukocytes in cellular blood components. Previous studies have evaluated these parameters mainly among older generation leuko-filters.</p><p><strong>Objective: </strong>This study evaluated the immediate effects of pre-storage leukoreduction on red cell indices and the performance efficacy of two newer generation leuko-filters.</p><p><strong>Methods: </strong>This retrospective analysis collected quality control data before and after leukoreduction for erythrocyte concentrates (ECs) from laboratory registers from the Blood Transfusion Laboratory at the Advanced Centre for Treatment, Research and Education in Cancer in Mumbai, India, for the period January 2015 to December 2019. Data related to red cell indices and performance characteristics for Fresenius and Macopharma filters were included.</p><p><strong>Results: </strong>A total of 500 records was included in the study. All EC units demonstrated a 99.99% leukocyte log reduction, with both filters showing equal efficacy. Post-leukoreduction haemoglobin concentrations were lower than the pre-leukoreduction for all units (<i>p</i> < 0.001). Of those prepared from 350 mL units, 11.6% (28/240) had haemoglobin levels under 40 g/bag as compared to 1.1% (3/260) among those prepared from 450 mL units. All indices exhibited statistically significant changes after leukoreduction (<i>p</i> < 0.001) except for mean corpuscular haemoglobin (<i>p</i> = 0.215). The Fresenius filter required less time for leukoreduction compared to the Macopharma filter (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Red cell indices show several changes following leukoreduction. Further studies are needed to assess the microscopic and functional impact of leukoreduction. Leuko-filters vary in their performance characteristics, which may influence vendor selection.</p><p><strong>What this study adds: </strong>This study found changes among several red cell indices after leukoreduction of ECs, which have not been extensively studied in previous literature. Further, we found that the newer generation leuko-filters differ in specific performance characteristics, which may influence vendor selection.</p>","PeriodicalId":45412,"journal":{"name":"African Journal of Laboratory Medicine","volume":"14 1","pages":"2723"},"PeriodicalIF":1.0000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223950/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of pre-storage leukoreduction on erythrocyte concentrates and performance of newer generation leuko-filters at a tertiary care oncology hospital in Western India.\",\"authors\":\"Deep Madkaiker, Shashank Ojha, Arunkumar N, Kalpesh Chawan\",\"doi\":\"10.4102/ajlm.v14i1.2723\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Leukoreduction is a post-processing technique that reduces residual leukocytes in cellular blood components. Previous studies have evaluated these parameters mainly among older generation leuko-filters.</p><p><strong>Objective: </strong>This study evaluated the immediate effects of pre-storage leukoreduction on red cell indices and the performance efficacy of two newer generation leuko-filters.</p><p><strong>Methods: </strong>This retrospective analysis collected quality control data before and after leukoreduction for erythrocyte concentrates (ECs) from laboratory registers from the Blood Transfusion Laboratory at the Advanced Centre for Treatment, Research and Education in Cancer in Mumbai, India, for the period January 2015 to December 2019. Data related to red cell indices and performance characteristics for Fresenius and Macopharma filters were included.</p><p><strong>Results: </strong>A total of 500 records was included in the study. All EC units demonstrated a 99.99% leukocyte log reduction, with both filters showing equal efficacy. Post-leukoreduction haemoglobin concentrations were lower than the pre-leukoreduction for all units (<i>p</i> < 0.001). Of those prepared from 350 mL units, 11.6% (28/240) had haemoglobin levels under 40 g/bag as compared to 1.1% (3/260) among those prepared from 450 mL units. All indices exhibited statistically significant changes after leukoreduction (<i>p</i> < 0.001) except for mean corpuscular haemoglobin (<i>p</i> = 0.215). The Fresenius filter required less time for leukoreduction compared to the Macopharma filter (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Red cell indices show several changes following leukoreduction. Further studies are needed to assess the microscopic and functional impact of leukoreduction. Leuko-filters vary in their performance characteristics, which may influence vendor selection.</p><p><strong>What this study adds: </strong>This study found changes among several red cell indices after leukoreduction of ECs, which have not been extensively studied in previous literature. Further, we found that the newer generation leuko-filters differ in specific performance characteristics, which may influence vendor selection.</p>\",\"PeriodicalId\":45412,\"journal\":{\"name\":\"African Journal of Laboratory Medicine\",\"volume\":\"14 1\",\"pages\":\"2723\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223950/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Journal of Laboratory Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4102/ajlm.v14i1.2723\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Journal of Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4102/ajlm.v14i1.2723","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Effects of pre-storage leukoreduction on erythrocyte concentrates and performance of newer generation leuko-filters at a tertiary care oncology hospital in Western India.
Background: Leukoreduction is a post-processing technique that reduces residual leukocytes in cellular blood components. Previous studies have evaluated these parameters mainly among older generation leuko-filters.
Objective: This study evaluated the immediate effects of pre-storage leukoreduction on red cell indices and the performance efficacy of two newer generation leuko-filters.
Methods: This retrospective analysis collected quality control data before and after leukoreduction for erythrocyte concentrates (ECs) from laboratory registers from the Blood Transfusion Laboratory at the Advanced Centre for Treatment, Research and Education in Cancer in Mumbai, India, for the period January 2015 to December 2019. Data related to red cell indices and performance characteristics for Fresenius and Macopharma filters were included.
Results: A total of 500 records was included in the study. All EC units demonstrated a 99.99% leukocyte log reduction, with both filters showing equal efficacy. Post-leukoreduction haemoglobin concentrations were lower than the pre-leukoreduction for all units (p < 0.001). Of those prepared from 350 mL units, 11.6% (28/240) had haemoglobin levels under 40 g/bag as compared to 1.1% (3/260) among those prepared from 450 mL units. All indices exhibited statistically significant changes after leukoreduction (p < 0.001) except for mean corpuscular haemoglobin (p = 0.215). The Fresenius filter required less time for leukoreduction compared to the Macopharma filter (p < 0.001).
Conclusion: Red cell indices show several changes following leukoreduction. Further studies are needed to assess the microscopic and functional impact of leukoreduction. Leuko-filters vary in their performance characteristics, which may influence vendor selection.
What this study adds: This study found changes among several red cell indices after leukoreduction of ECs, which have not been extensively studied in previous literature. Further, we found that the newer generation leuko-filters differ in specific performance characteristics, which may influence vendor selection.
期刊介绍：
The African Journal of Laboratory Medicine, the official journal of ASLM, focuses on the role of the laboratory and its professionals in the clinical and public healthcare sectors,and is specifically based on an African frame of reference. Emphasis is on all aspects that promote and contribute to the laboratory medicine practices of Africa. This includes, amongst others: laboratories, biomedical scientists and clinicians, medical community, public health officials and policy makers, laboratory systems and policies (translation of laboratory knowledge, practices and technologies in clinical care), interfaces of laboratory with medical science, laboratory-based epidemiology, laboratory investigations, evidence-based effectiveness in real world (actual) settings.
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