通过瞬态氢键矩阵的量子磁化交换定义了中枢神经系统的磁共振信号弛豫和各向异性。

IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Dmitriy A Yablonskiy, Alexander L Sukstanskii
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引用次数: 0

摘要

覆盖轴突的细胞膜(脂质双层)和髓鞘的完整性是控制正常脑结构和功能网络的关键特征。然而,在纳米水平上对细胞膜组织的完整性进行体内评估是具有挑战性的。本文探讨了生物水在中枢神经系统(CNS)中的双重特性,它既是细胞膜的主要稳定因子之一,又是MRI信号的主要来源。我们介绍了磁流变信号弛豫的基本瞬态氢键(THB)模型,该模型是由包含水分子和形成膜的大分子的THB矩阵内的量子自旋/磁化交换引起的。我们的数据显示存在两种具有不同寿命的THB矩阵成分-一种在几纳秒范围内,另一种在几十纳秒范围内。重要的是,前者有助于磁流变信号的纵向弛豫,后者有助于磁流变信号的横向弛豫,并导致磁流变信号弛豫的各向异性。这些独特的特征为研究细胞膜的纳米级微观结构提供了机会。此外,基于其MR信号松弛特性区分不同THB基质成分的能力对于识别病理变化和增强MRI扫描上的疾病可见性至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system.

Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system.

Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system.

Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system.

The integrity of cellular membranes (lipid bilayers) and myelin sheaths covering axons is a crucial feature controlling normal brain structural and functional networks. Yet, in vivo evaluation of this integrity at the nanoscale level of the cellular membranes organization is challenging. Herein we explore the dual property of biological water in Central Nervous System (CNS), as one of the major stabilizing factors of cellular membranes, and the major source of MRI signal. We introduce the Basic Transient Hydrogen Bond (THB) model of the MR signal relaxation due to the quantum spin/magnetization exchanges within the THB Matrix encompassing water molecules and membrane-forming macromolecules. Our data show the existence of two THB Matrix components with distinct lifetimes - one in a few nano-second range, and another in the range of tens nanoseconds. Importantly, the former component facilitates longitudinal relaxation of MR signal, the latter contributes to its transverse relaxation and causes the anisotropy of MR signal relaxation. These distinct features offer opportunity to study nanoscale level microstructure of cellular membranes. Furthermore, the ability to differentiate distinct THB Matrix components based on their MR signal relaxation properties can be fundamental to identifying pathological changes and enhancing disease visibility on MRI scans.

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来源期刊
Scientific Reports
Scientific Reports Natural Science Disciplines-
CiteScore
7.50
自引率
4.30%
发文量
19567
审稿时长
3.9 months
期刊介绍: We publish original research from all areas of the natural sciences, psychology, medicine and engineering. You can learn more about what we publish by browsing our specific scientific subject areas below or explore Scientific Reports by browsing all articles and collections. Scientific Reports has a 2-year impact factor: 4.380 (2021), and is the 6th most-cited journal in the world, with more than 540,000 citations in 2020 (Clarivate Analytics, 2021). •Engineering Engineering covers all aspects of engineering, technology, and applied science. It plays a crucial role in the development of technologies to address some of the world''s biggest challenges, helping to save lives and improve the way we live. •Physical sciences Physical sciences are those academic disciplines that aim to uncover the underlying laws of nature — often written in the language of mathematics. It is a collective term for areas of study including astronomy, chemistry, materials science and physics. •Earth and environmental sciences Earth and environmental sciences cover all aspects of Earth and planetary science and broadly encompass solid Earth processes, surface and atmospheric dynamics, Earth system history, climate and climate change, marine and freshwater systems, and ecology. It also considers the interactions between humans and these systems. •Biological sciences Biological sciences encompass all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants. •Health sciences The health sciences study health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
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