Helicobacter pylori associated MicroRNA and transcriptional networks in gastric pathogenesis: Exploring the epigenetic dialogue landscape

The pathogenicity of Helicobacter pylori infection is a well-documented risk factor for gastric ailments such as ulcer and cancer. However, the molecular mechanisms that underlie its pathogenic effects are only partially understood. To address the research gap, this study utilizes a comprehensive bioinformatic approach to identify key microRNAs (miRNAs) that target high-risk genes associated with H. pylori at an epigenetic level. The miRNAs in question, including hsa-mir-539, hsa-mir-361, hsa-mir-203a, hsa-mir-7-1, hsa-let-7f-1, hsa-mir-133a-1, and hsa-mir-186, were validated through rigorous database searches and cross-referencing. By curating the miRNet and other miRNA platforms, the study uncovered intricate regulatory networks between these miRNAs and transcription factors (TFs) such as androgen receptor (AR), BCL6, and GATA1. These interactions play a crucial role in inflammatory and carcinogenic pathways. The functional annotation of the miRNAs highlights their significant roles in essential biological processes and pathways that are relevant to H. pylori infection and gastric cancer progression. Overall, this integrated analysis provides critical insights into the molecular landscape of H. pylori-induced ulceration and carcinogenesis. This information may offer potential biomarkers and therapeutic targets for future research and clinical applications in managing gut health.