结核分枝杆菌耐药机制研究进展。

IF 3.3 3区医学 Q3 IMMUNOLOGY

Microbial pathogenesis Pub Date : 2025-09-01 Epub Date: 2025-07-01 DOI:10.1016/j.micpath.2025.107861

Muhammad Sikandar, Li Xing

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引用次数: 0

摘要

结核分枝杆菌（Mycobacterium tuberculosis, Mtb）是结核病的病原体，它对抗微生物药物治疗产生了不同的作用机制，对结核分枝杆菌的有效治疗构成了重大威胁。本文综述了结核分枝杆菌耐药机制的最新进展，并重点介绍了药物如何靶向特定的细胞过程。此外，我们还讨论了Mtb采用的内在耐药机制以及药物靶点的改变如何导致治疗失败。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in the mechanisms of drug resistance of Mycobacteriumtuberculosis.

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has developed different mechanism of action against antimicrobial drug therapies, posing a significant threat to effective treatment against Mtb. This review article provides an overview of the recent advancements in the mechanism of drug resistance in Mtb and highlights how drugs target specific cellular processes. Additionally, we also discuss the intrinsic resistance mechanisms employed by Mtb and how alterations in drug target sites contribute to treatment failure.

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来源期刊

Microbial pathogenesis 医学-免疫学

CiteScore

7.40

自引率

2.60%

发文量

472

审稿时长

56 days

期刊介绍： Microbial Pathogenesis publishes original contributions and reviews about the molecular and cellular mechanisms of infectious diseases. It covers microbiology, host-pathogen interaction and immunology related to infectious agents, including bacteria, fungi, viruses and protozoa. It also accepts papers in the field of clinical microbiology, with the exception of case reports. Research Areas Include: -Pathogenesis -Virulence factors -Host susceptibility or resistance -Immune mechanisms -Identification, cloning and sequencing of relevant genes -Genetic studies -Viruses, prokaryotic organisms and protozoa -Microbiota -Systems biology related to infectious diseases -Targets for vaccine design (pre-clinical studies)