来自随机对照交叉CocoHeart研究的发现:与一般健康男性的不饱和脂肪相比,连续膳食含有动物和植物饱和脂肪对餐后肠道激素有不同的影响,但对饱腹感没有影响。

IF 3.7 3区 医学 Q2 NUTRITION & DIETETICS
Gloria Wong, Miriam E Clegg, Damian Ross, Julie A Lovegrove, Kim G Jackson
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引用次数: 0

摘要

背景:与不饱和脂肪相比,富含饱和脂肪(SFA)的食物通常与餐后甘油三酯反应升高有关。尽管椰子油在英国饮食中越来越受欢迎,但这种富含sfa的油对餐后血脂和生理食欲反应的影响尚不清楚。目的:本研究比较了富含黄油和椰子油的连续高脂肪测试餐与植物油混合物(红花和橄榄油)在健康男性餐后甘油三酯(主要结局)、血脂、葡萄糖和肠道激素反应以及食欲的生理指标。方法:在一项单盲、随机急性三臂交叉研究中,13名男性(53±3岁,BMI 24.4±3.0 kg/m2)连续三次食用含有富含sfa的油/脂肪或植物油混合物(早餐53.6 g,午餐33.6 g脂肪)的试验餐,每次间隔四周。在早餐前和早餐后480分钟内定期采集血液样本和饱腹感评分。在0,150,300和480分钟测量血压和动脉硬度。餐后数据使用线性混合模型和ANCOVA饱腹感评分进行分析。结果:餐后甘油三酯、葡萄糖、胰岛素、胃促生长素、血压和动脉僵硬度或感知饱腹感反应在测试脂肪/油之间相似。与富含sfa的膳食相比,植物油餐后葡萄糖依赖的促胰岛素多肽反应的曲线下增量面积(iAUC)更高,而黄油餐后胰高血糖素样肽-1反应低于富含椰子和植物油餐(p≤0.012)。食用黄油后肽YY反应的iAUC低于食用椰子油后(p≤0.048),但与食用植物油后无显著差异。结论:尽管脂肪酸组成不同,餐后甘油三酯反应在脂肪/油之间是相似的。我们的研究结果表明,与不饱和脂肪相比,黄油和椰子油对肠道激素反应的影响有所不同,但对一般健康男性的饱腹感没有影响。临床试验注册:(唯一标识符:NCT05264233)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sequential Meals Containing Animal and Plant-Based Saturated Fats Have Differential Effects on Postprandial Gut Hormones but No Impact on Satiety Compared with Unsaturated Fats in Generally Healthy Males: Findings from the Randomized Controlled Crossover CocoHeart Study.

Background: Saturated fat (SFA)-rich meals are often linked to elevated postprandial triacylglycerol responses compared with unsaturated fats. Despite the growing popularity of coconut oil in the United Kingdom diet, effects of this SFA-rich oil on postprandial lipemia and physiological appetite responses are unclear.

Objectives: This study compared sequential high-fat test meals rich in butter and coconut oil with a vegetable oil blend (safflower and olive oil) on postprandial triacylglycerol (primary outcome), lipids, glucose, and gut hormones responses, and physiological measures of appetite in healthy males.

Methods: In a single-blind, randomized acute 3-armed crossover study, 13 males (53 ± 3 years, body mass index 24.4 ± 3.0 kg/m2) consumed sequential test meals containing SFA-rich oils/fats or a vegetable oil blend (breakfast 53.6 g and lunch 33.6 g fat) on 3 occasions, each separated by a 4-wk period. Blood samples and satiety ratings were collected prior to and at regular intervals over 480 min posttest breakfast. Blood pressure and arterial stiffness were measured at 0, 150, 300, and 480 min. Postprandial data were analyzed using linear mixed models and satiety ratings using analysis of covariance.

Results: Postprandial triacylglycerol, glucose, insulin, ghrelin, blood pressure, and arterial stiffness or perceived satiety responses were similar between the test fat/oils. The incremental area under the curve (iAUC) for the postprandial glucose-dependent insulinotropic polypeptide response was higher with vegetable oil compared with the SFA-rich meals whereas the glucagon-like peptide-1 response was lower after the butter than coconut and vegetable oil-rich meals (P ≤ 0.012). The iAUC for the peptide YY response was lower after butter than coconut oil-rich meals (P ≤ 0.048), but not different compared with vegetable oil.

Conclusions: Despite varying fatty acid compositions, postprandial triacylglycerol responses were similar between fats/oils. Our findings suggest that butter and coconut oil have differential effects on gut hormone responses compared with unsaturated fats without an impact on satiety in generally healthy males.

Trial registration number: NCT05264233.

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来源期刊
Journal of Nutrition
Journal of Nutrition 医学-营养学
CiteScore
7.60
自引率
4.80%
发文量
260
审稿时长
39 days
期刊介绍: The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.
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