从昆虫病原真菌蜜蜂中分离得到的三个新的莽草碱共轭角萜类化合物。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-07-04 DOI:10.1080/10286020.2025.2521542

Ya-Nan Tian, Yu-Wei Niu, Ke-Liang Chen, Yang Liu, Chen-Yu Yang, Xing-Bao Jia, Yang Yang, Yun-Bao Liu

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引用次数: 0

摘要

从亚洲蜜蜂内生真菌Alternaria alternarenes中分离到3个新的牛草酸共轭二萜类化合物tricycloalternarenes Z1-Z3（1-3）。新化合物的结构通过NMR和hresms数据进行了表征。通过电子圆二色性（ECD）计算和CD光谱确定了绝对构型。生物实验结果显示，三环交替芳烃Z1(1)对lps诱导的RAW 264.7细胞NO生成具有中等抗炎活性，IC50值为0.93µM。

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Three new shikimate-conjugated meroterpenoids from Alternaria alternata isolated from an entomopathogenic fungus Apis mellifera.

Three new shikimate-conjugated meroterpenes, tricycloalternarenes Z1-Z3 (1-3), were isolated from Alternaria alternate, an endophytic fungus residing in Apis mellifera. The structures of new compounds were characterized by analyses of their NMR and HRESIMS data. The absolute configurations were assigned through electronic circular dichroism (ECD) calculations and CD spectra. Bioassay results showed that tricycloalternarene Z1 (1) exhibited moderate anti-inflammatory activity against the LPS-induced production of NO in RAW 264.7 cells, with an IC₅₀ value of 0.93 µM.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.