{"title":"乳制品乳酸菌对高脂饲料喂养大鼠脂质模式的影响。","authors":"Sahar Fouladi, Elham Moazamian","doi":"10.18502/ijm.v17i3.18826","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>A unique characteristic of probiotics is obesity and fatty liver control. In this study, the effect of lactic-acid-bacteria (LABs) isolated from dairy products was investigated on weight changes, blood biochemical indexes and liver tissue in mice fed a high-fat diet.</p><p><strong>Materials and methods: </strong>A total of 49 rats were assigned to 7 groups. The LAB-treated groups received the high-cholesterol diet supplemented with <i>Lactobacillus reuteri, Lactobacillus plantarum</i>, and <i>Bifidobacterium animalis</i> isolated from yogurt. At the end of 4 weeks, body weight changes, lipid factors and liver enzymes as well as liver lipid deposition and adipocyte size were measured.</p><p><strong>Results: </strong>Serum low-density lipoprotein, total cholesterol, triglyceride levels and hepatic lipid deposition were significantly decreased in rats treated with LABs. The maximum and minimum weights were observed in the first and fourth weeks after treating with <i>Lactobacillus</i> and <i>Bifidobacterium</i> isolates, respectively. Liver enzymes were significantly decreased by LABs, especially in the group receiving concomitant administration of <i>Lactobacillus</i> and <i>Bifidobacterium</i>. Fatty liver process was reduced in the fat-fed group treated with <i>L. reuteri.</i></p><p><strong>Conclusion: </strong>LABs caused decreases in body weight gain, liver function, and adipocyte size. Therefore, coadministration of <i>Lactobacillus</i> and <i>Bifidobacterium</i> in dairy products can significantly decrease lipid profile.</p>","PeriodicalId":14633,"journal":{"name":"Iranian Journal of Microbiology","volume":"17 3","pages":"434-440"},"PeriodicalIF":1.7000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218888/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet.\",\"authors\":\"Sahar Fouladi, Elham Moazamian\",\"doi\":\"10.18502/ijm.v17i3.18826\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>A unique characteristic of probiotics is obesity and fatty liver control. In this study, the effect of lactic-acid-bacteria (LABs) isolated from dairy products was investigated on weight changes, blood biochemical indexes and liver tissue in mice fed a high-fat diet.</p><p><strong>Materials and methods: </strong>A total of 49 rats were assigned to 7 groups. The LAB-treated groups received the high-cholesterol diet supplemented with <i>Lactobacillus reuteri, Lactobacillus plantarum</i>, and <i>Bifidobacterium animalis</i> isolated from yogurt. At the end of 4 weeks, body weight changes, lipid factors and liver enzymes as well as liver lipid deposition and adipocyte size were measured.</p><p><strong>Results: </strong>Serum low-density lipoprotein, total cholesterol, triglyceride levels and hepatic lipid deposition were significantly decreased in rats treated with LABs. The maximum and minimum weights were observed in the first and fourth weeks after treating with <i>Lactobacillus</i> and <i>Bifidobacterium</i> isolates, respectively. Liver enzymes were significantly decreased by LABs, especially in the group receiving concomitant administration of <i>Lactobacillus</i> and <i>Bifidobacterium</i>. Fatty liver process was reduced in the fat-fed group treated with <i>L. reuteri.</i></p><p><strong>Conclusion: </strong>LABs caused decreases in body weight gain, liver function, and adipocyte size. Therefore, coadministration of <i>Lactobacillus</i> and <i>Bifidobacterium</i> in dairy products can significantly decrease lipid profile.</p>\",\"PeriodicalId\":14633,\"journal\":{\"name\":\"Iranian Journal of Microbiology\",\"volume\":\"17 3\",\"pages\":\"434-440\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218888/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18502/ijm.v17i3.18826\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/ijm.v17i3.18826","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Effects of lactic acid bacteria isolated from dairy products on lipid pattern of rats fed with a high fat diet.
Background and objectives: A unique characteristic of probiotics is obesity and fatty liver control. In this study, the effect of lactic-acid-bacteria (LABs) isolated from dairy products was investigated on weight changes, blood biochemical indexes and liver tissue in mice fed a high-fat diet.
Materials and methods: A total of 49 rats were assigned to 7 groups. The LAB-treated groups received the high-cholesterol diet supplemented with Lactobacillus reuteri, Lactobacillus plantarum, and Bifidobacterium animalis isolated from yogurt. At the end of 4 weeks, body weight changes, lipid factors and liver enzymes as well as liver lipid deposition and adipocyte size were measured.
Results: Serum low-density lipoprotein, total cholesterol, triglyceride levels and hepatic lipid deposition were significantly decreased in rats treated with LABs. The maximum and minimum weights were observed in the first and fourth weeks after treating with Lactobacillus and Bifidobacterium isolates, respectively. Liver enzymes were significantly decreased by LABs, especially in the group receiving concomitant administration of Lactobacillus and Bifidobacterium. Fatty liver process was reduced in the fat-fed group treated with L. reuteri.
Conclusion: LABs caused decreases in body weight gain, liver function, and adipocyte size. Therefore, coadministration of Lactobacillus and Bifidobacterium in dairy products can significantly decrease lipid profile.
期刊介绍：
The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.
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