提高胃癌患者的初始分期：[99mTc]-FAPI-46 SPECT/CT相对于传统CT的优势

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-07-04 DOI:10.1097/RLU.0000000000005794

Haniye Elahifard, Mohammad Hadi Samadi, Kamran Aryana, Hassan Kamali, Somaye Barashki

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引用次数: 0

摘要

我们报告一位59岁的男性胃印戒细胞癌，最初通过增强CT （CECT）分期，显示胃壁增厚，淋巴结和肺转移。随后，[99mTc]-FAPI-46 SPECT/CT显示胃病变、肺结节和淋巴结的示踪剂摄取增加，同时骨骼转移、大网膜和腹膜沉积的新发现，改变了分期和临床处理。我们的研究结果强调了[99mTc]-FAPI-46在准确分期胃癌和发现隐匿转移性病变方面的优势，这对有效的治疗计划至关重要，尽管与诊断性腹腔镜相比存在一些局限性。

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Enhancing Initial Staging of a Gastric Cancer Patient: The Advantage of [ 99m Tc]-FAPI-46 SPECT/CT Over Conventional CT.

We present a 59-year-old man with gastric signet-ring cell carcinoma, initially staged with contrast-enhanced CT (CECT), revealing gastric wall thickening, lymph nodes, and lung metastases. Subsequently, [ 99m Tc]-FAPI-46 SPECT/CT demonstrated increased tracer uptake in the gastric lesion, pulmonary nodule, and lymph nodes, alongside new findings of skeletal metastasis, omental and peritoneal deposits, altering the staging and clinical management. Our findings highlight the superior utility of [ 99m Tc]-FAPI-46 in accurately staging gastric cancer and detecting occult metastatic lesions, which is critical for effective treatment planning, despite some limitations compared which diagnostic laparoscopy.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.