伊拉克安巴尔省乙型和丙型肝炎感染的流行病学及病毒载量与肝功能的相关性

IF 1.4 Q4 VIROLOGY
Advances in Virology Pub Date : 2025-06-26 eCollection Date: 2025-01-01 DOI:10.1155/av/9970549
Mohammed A Hamad, Ala'a F Habeeb, Nabaa A Muhammed, Rawaa A Muhammed
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引用次数: 0

摘要

目的:乙型肝炎(HBV)和丙型肝炎(HCV)是世界范围内的一个严重的健康问题,其污染和传播的风险是通过日常活动和与受感染患者的接触,以及其显著的不良反应和沉默携带者的存在。诊断随着技术的发展而发展,使用了更具体的技术。目的是研究安巴尔省(费卢杰和阿米里耶)HBV和HCV的流行病学和分子检测,以及HBV和HCV病毒载量与肝功能的相关性。材料和方法:从费卢杰和阿米里耶医院以及私人实验室收集了5463例HBV病毒感染检测和5873例HBV病毒感染患者信息,这些患者于2021年1月15日至2021年11月20日期间使用问卷进行HBV或HCV检测,并通过快速检测进行诊断,阳性结果采用ELISA检测,样品采用q-PCR技术检测。研究结果:在研究队列中,HBV感染的患病率高于HCV,在女性和年轻人(29-30岁)中影响最大。此外,与HBV相比,hcv感染患者的病毒载量较高。最后,与HBV相比,hcv感染患者的肝酶(ALP、AST和ALT)显著升高。结论:女性HBV感染率高,病程进展快,肝酶病变多。受影响最大的年龄组是交际和经济活动最多的青壮年群体,随着HCV病毒载量的增加,对肝脏的影响增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epidemiology of Hepatitis B and C Infections in Al-Anbar/Iraq and Correlation Between Viral Load and Liver Function.

Aims: Hepatitis B (HBV) and C (HCV) represent a menacing health problem worldwide and its risk of contamination and transmission by routine activities and contact with infected patients and its remarkable adverse effects and presence of silent carriers. The diagnosis developed with the developing techniques using more specific techniques. The aim is to study the epidemiology and molecular detection of HBV and HCV in the Anbar governorate (Fallujah and Amiriyah) and the correlation between the viral load of HBV and HCV on liver functions. Materials and Methods: A cohort of 5463 tested for HBV viral infection and 5873 tested for HBV viral infection patients' information were collected from units in Fallujah and Amiriyah Hospitals as well as private laboratories who sent for HBV or HCV detection from 15th January 2021 to 20th November 2021 using a questionnaire and diagnosed with rapid tests, the positive results subjected for testing with ELISA and samples tested using q-PCR techniques. Findings: Among the studied cohort, the prevalence of HBV infections was high compared to HCV, with the highest impact in females and the ages of young adults (29-30 years). Furthermore, viral loads were high in HCV-infected patients compared to HBV. Finally, liver enzymes (ALP, AST, and ALT) were significantly high in HCV-infected patients compared to HBV. Conclusion: The study concluded that females have a higher rate of infection with higher progression of the HBV and more morbid liver enzymes. The highest affected age groups are the highest communicational and economic activity group of young adults with elevated impact on the liver with HCV viral load increasing.

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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
23
审稿时长
22 weeks
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