休战-微笑重排法合成烷基（邻苯基）芳基亚砜。

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-07-03 DOI:10.1021/acs.joc.5c00969

Zhaoqing Zhang, Xinping Zhang, Runyu Jia and Tiezheng Jia*,

引用次数: 0

摘要

研究了一种原子经济性和化学选择性的烷基（邻苯基）芳基亚砜合成方法。由杂芳基（正烷基）-芳基亚砜的休战-微笑重排产生的亚砜阴离子被伯烷基卤化物捕获以传递相应的亚砜。设计了一个休战-微笑重排/环化级联，以扩大仲环烷基亚砜的范围。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of Alkyl (ortho-Benzyl)-Aryl Sulfoxides Enabled by Truce-Smiles Rearrangement

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Synthesis of Alkyl (ortho-Benzyl)-Aryl Sulfoxides Enabled by Truce-Smiles Rearrangement

An atom-economical and chemoselective synthesis of alkyl (ortho-benzyl)-aryl sulfoxides has been developed. Sulfenate anions, which were generated by the Truce-Smiles rearrangement of heteroaryl (ortho-alkyl)-aryl sulfoxides, have been trapped by primary alkyl halides to deliver the corresponding sulfoxides. A Truce-Smiles rearrangement/cyclization cascade has been designed to expand the scope of secondary cycloalkyl sulfoxides.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.