海马体神经发生：桥接压力、认知衰退和神经健康的治疗策略

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-07-03 DOI:10.1016/j.bbr.2025.115720

Vivek Kumar Sharma , Preety Sharma , Ashi Mannan , Sonia Dhiman , Maneesh Mohan , Shareen Singh , Thakur Gurjeet Singh

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引用次数: 0

摘要

海马体在空间和情境学习中起着至关重要的作用，其与年龄相关的衰退显著导致认知障碍。成年海马神经发生（AHN）是齿状回中不断产生的新神经元，为终身学习和记忆提供了一种独特的结构可塑性形式。AHN在各种以认知缺陷为特征的神经退行性疾病和精神健康疾病中发生显著改变，表明其在维持神经元种群和内源性再生能力方面发挥了重要作用。鉴于神经发生与这些疾病之间的联系，神经发生疗法有望改善严重抑郁症、认知障碍和其他神经退行性疾病患者的预后。值得注意的是，慢性应激是影响AHN的重要因素，通常作为痴呆的独立生物标志物，并强烈影响海马神经发生。这篇综述探讨了压力对AHN的复杂影响，并研究了神经发生的抑制如何导致认知缺陷和痴呆的进展。

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Hippocampal neurogenesis: Bridging stress, cognitive decline, and therapeutic strategies for neural health

The hippocampus plays a critical role in spatial and contextual learning, and its age-related decline significantly contributes to cognitive impairment. Adult hippocampal neurogenesis (AHN), the continuous production of new neurons in the dentate gyrus, provides a unique form of structural plasticity essential for lifelong learning and memory. AHN is notably altered in various neurodegenerative and mental health disorders characterized by cognitive deficits, suggesting its crucial involvement in maintaining neuronal populations and endogenous regenerative capacity. Given the emerging links between neurogenesis and these conditions, neurogenic therapies hold promise for improving outcomes in individuals with severe depression, cognitive impairment, and other neurodegenerative disorders. Notably, chronic stress is a significant factor influencing AHN, often serving as an independent biomarker for dementia and strongly impacting hippocampal neurogenesis. This review explores the intricate influence of stress on AHN and examines how the inhibition of neurogenesis contributes to cognitive deficits and the progression of dementia.

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.