Janke Kleynhans, Christiaan A Gouws, Thomas Ebenhan
{"title":"分枝杆菌感染的PET显像：改变结核病药物开发的管道。","authors":"Janke Kleynhans, Christiaan A Gouws, Thomas Ebenhan","doi":"10.1038/s44303-025-00082-2","DOIUrl":null,"url":null,"abstract":"<p><p>Improved PET/CT radiopharmaceuticals can better visualize and monitor tuberculosis and enable real-time pharmacological drug profiling in vivo. PET/CT imaging can therefore be used to study in animal models the changes in tissue pathology in tuberculosis infection, such as mycobacterial latency, tuberculoma formation, lung cavitation or calcification, and extrapulmonary disease. This Perspective aims to critically evaluate the current and future contribution and role of PET imaging in anti-tuberculosis drug development.</p>","PeriodicalId":501709,"journal":{"name":"npj Imaging","volume":"3 1","pages":"22"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441125/pdf/","citationCount":"0","resultStr":"{\"title\":\"PET imaging of mycobacterial infection: transforming the pipeline for tuberculosis drug development.\",\"authors\":\"Janke Kleynhans, Christiaan A Gouws, Thomas Ebenhan\",\"doi\":\"10.1038/s44303-025-00082-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Improved PET/CT radiopharmaceuticals can better visualize and monitor tuberculosis and enable real-time pharmacological drug profiling in vivo. PET/CT imaging can therefore be used to study in animal models the changes in tissue pathology in tuberculosis infection, such as mycobacterial latency, tuberculoma formation, lung cavitation or calcification, and extrapulmonary disease. This Perspective aims to critically evaluate the current and future contribution and role of PET imaging in anti-tuberculosis drug development.</p>\",\"PeriodicalId\":501709,\"journal\":{\"name\":\"npj Imaging\",\"volume\":\"3 1\",\"pages\":\"22\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441125/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"npj Imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s44303-025-00082-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s44303-025-00082-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
PET imaging of mycobacterial infection: transforming the pipeline for tuberculosis drug development.
Improved PET/CT radiopharmaceuticals can better visualize and monitor tuberculosis and enable real-time pharmacological drug profiling in vivo. PET/CT imaging can therefore be used to study in animal models the changes in tissue pathology in tuberculosis infection, such as mycobacterial latency, tuberculoma formation, lung cavitation or calcification, and extrapulmonary disease. This Perspective aims to critically evaluate the current and future contribution and role of PET imaging in anti-tuberculosis drug development.
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