{"title":"妊娠期糖尿病妇女口服葡萄糖耐量试验不同反应模式与产后葡萄糖耐受不良的关系","authors":"Jianing Bi, Li Zhang, Jing Peng, Yunshu Yang, Jing Jin, Qing Liu, Gaojie Fan, Qing Fang, Youjie Wang, Lulu Song, Guocheng Liu","doi":"10.1007/s12020-025-04327-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Our study aimed to assess the associations of the response patterns during gestational oral glucose tolerance test (OGTT) with postpartum glucose intolerance (PGI) in women with gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>This cohort study included 5348 GDM women who underwent the OGTT both 24-28 weeks during pregnancy and 4-12 weeks postpartum from January 2017 to June 2022. Gestational OGTT response patterns included individual time-point glucose values, glucose response trajectories, and GDM subtypes. PGI was defined as women with postpartum pre-diabetes or diabetes. Cox proportional hazards regression models were used to assess the risks of PGI according to different response patterns.</p><p><strong>Results: </strong>During a median follow-up of 6.3 weeks post-delivery, 1727 (32.3%) women had PGI. Each time-point OGTT glucose were positively associated with PGI. Four OGTT glucose trajectories were fitted: 515 (9.6%) moderate increase following decrease, 557 (10.4%) sustained low-level increase, 3918 (73.3%) moderate increase following slow decrease, and 358 (6.7%) rapid increase following slow decrease. Compared with women with glucose moderate increase following decrease, those with rapid increase following slow decrease had the highest risk of PGI, followed by those with moderate increase following slow decrease. For GDM subtypes, 442 (8.3%) were isolated fasting hyperglycemia (IFH), 4227 (79.0%) were isolated post-load hyperglycemia (IPH), and 679 (12.7%) were combined hyperglycemia (CH). Compared with women with IFH, CH indicated the highest risk of PGI, followed by IPH.</p><p><strong>Conclusions: </strong>Our findings indicate that distinct OGTT response patterns are associated with varying risks of PGI in women with GDM.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"31-38"},"PeriodicalIF":2.9000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between different response patterns during oral glucose tolerance test and postpartum glucose intolerance in women with gestational diabetes.\",\"authors\":\"Jianing Bi, Li Zhang, Jing Peng, Yunshu Yang, Jing Jin, Qing Liu, Gaojie Fan, Qing Fang, Youjie Wang, Lulu Song, Guocheng Liu\",\"doi\":\"10.1007/s12020-025-04327-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Our study aimed to assess the associations of the response patterns during gestational oral glucose tolerance test (OGTT) with postpartum glucose intolerance (PGI) in women with gestational diabetes mellitus (GDM).</p><p><strong>Methods: </strong>This cohort study included 5348 GDM women who underwent the OGTT both 24-28 weeks during pregnancy and 4-12 weeks postpartum from January 2017 to June 2022. Gestational OGTT response patterns included individual time-point glucose values, glucose response trajectories, and GDM subtypes. PGI was defined as women with postpartum pre-diabetes or diabetes. Cox proportional hazards regression models were used to assess the risks of PGI according to different response patterns.</p><p><strong>Results: </strong>During a median follow-up of 6.3 weeks post-delivery, 1727 (32.3%) women had PGI. Each time-point OGTT glucose were positively associated with PGI. Four OGTT glucose trajectories were fitted: 515 (9.6%) moderate increase following decrease, 557 (10.4%) sustained low-level increase, 3918 (73.3%) moderate increase following slow decrease, and 358 (6.7%) rapid increase following slow decrease. Compared with women with glucose moderate increase following decrease, those with rapid increase following slow decrease had the highest risk of PGI, followed by those with moderate increase following slow decrease. For GDM subtypes, 442 (8.3%) were isolated fasting hyperglycemia (IFH), 4227 (79.0%) were isolated post-load hyperglycemia (IPH), and 679 (12.7%) were combined hyperglycemia (CH). Compared with women with IFH, CH indicated the highest risk of PGI, followed by IPH.</p><p><strong>Conclusions: </strong>Our findings indicate that distinct OGTT response patterns are associated with varying risks of PGI in women with GDM.</p>\",\"PeriodicalId\":49211,\"journal\":{\"name\":\"Endocrine\",\"volume\":\" \",\"pages\":\"31-38\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12020-025-04327-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-025-04327-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/2 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Association between different response patterns during oral glucose tolerance test and postpartum glucose intolerance in women with gestational diabetes.
Purpose: Our study aimed to assess the associations of the response patterns during gestational oral glucose tolerance test (OGTT) with postpartum glucose intolerance (PGI) in women with gestational diabetes mellitus (GDM).
Methods: This cohort study included 5348 GDM women who underwent the OGTT both 24-28 weeks during pregnancy and 4-12 weeks postpartum from January 2017 to June 2022. Gestational OGTT response patterns included individual time-point glucose values, glucose response trajectories, and GDM subtypes. PGI was defined as women with postpartum pre-diabetes or diabetes. Cox proportional hazards regression models were used to assess the risks of PGI according to different response patterns.
Results: During a median follow-up of 6.3 weeks post-delivery, 1727 (32.3%) women had PGI. Each time-point OGTT glucose were positively associated with PGI. Four OGTT glucose trajectories were fitted: 515 (9.6%) moderate increase following decrease, 557 (10.4%) sustained low-level increase, 3918 (73.3%) moderate increase following slow decrease, and 358 (6.7%) rapid increase following slow decrease. Compared with women with glucose moderate increase following decrease, those with rapid increase following slow decrease had the highest risk of PGI, followed by those with moderate increase following slow decrease. For GDM subtypes, 442 (8.3%) were isolated fasting hyperglycemia (IFH), 4227 (79.0%) were isolated post-load hyperglycemia (IPH), and 679 (12.7%) were combined hyperglycemia (CH). Compared with women with IFH, CH indicated the highest risk of PGI, followed by IPH.
Conclusions: Our findings indicate that distinct OGTT response patterns are associated with varying risks of PGI in women with GDM.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
