药师主导的干预措施对60岁及以上人群COVID-19、带状疱疹、流感、肺炎球菌和呼吸道合胞病毒疫苗摄入的影响：系统评价和荟萃分析

IF 2.8 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Research in Social & Administrative Pharmacy Pub Date : 2025-07-01 DOI:10.1016/j.sapharm.2025.06.110

Shambel Nigussie Amare , Kwang Choon Yee , Myra Leung , Mark Naunton , Mary Bushell

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引用次数: 0

摘要

背景：虽然一些回顾性研究评估了药剂师在疫苗接种服务中的作用，但没有一项研究全面评估了药剂师在所有主要推荐疫苗中提高老年人疫苗接种率的具体影响。这些包括COVID-19、带状疱疹、流感、肺炎球菌病和呼吸道合胞病毒。本系统综述旨在为药师主导的干预措施在促进60岁及以上人群接种这些疫苗方面的有效性提供证据。方法：综合检索Web of Science、PubMed、Embase、Cochrane Central Register of Controlled Trials、Scopus、谷歌Scholar等6个数据库中截至2024年6月的相关出版物。使用随机效应模型估计合并效应大小，置信区间为95%。采用亚组分析来评估药师角色的效应量差异。结果：初步纳入10998项研究，其中13项符合纳入标准。在8项前后研究中，药剂师参与免疫接种服务显著增加了老年人的疫苗接种率，总相对危险度（RR）为3.29 （95% CI: 2.01-5.39）。同样，在5项随机研究中，药剂师主导的干预措施与疫苗接种增加显著相关，合并RR为3.04 （95% CI: 1.46-6.34）。结论：本综述证明了药师主导的干预措施对老年人疫苗接种的实质性影响。研究结果表明，当药剂师担任教育者、促进者、免疫者和倡导者时，会出现最大的改善。卫生保健政策制定者和组织应该优先考虑和实施全面的药剂师主导的战略，以提高这一人群的疫苗吸收率。

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Impact of pharmacist-led interventions on COVID-19, herpes zoster, influenza, pneumococcal, and respiratory syncytial virus vaccines uptake in people aged 60 years and older: Systematic review and meta-analysis

Background

While some review studies have assessed the role of pharmacists in vaccination services, none have comprehensively assessed their impact specifically on improving vaccination uptake among older adults across all major recommended vaccines. These include COVID-19, herpes zoster, influenza, pneumococcal disease, and respiratory syncytial virus. This systematic review aimed to generate evidence on the effectiveness of pharmacist-led interventions in promoting the uptake of these vaccines among individuals aged 60 years and older.

Method

Relevant publications up to June 2024 were comprehensively searched across six databases: Web of Science, PubMed, Embase, Cochrane Central Register of Controlled Trials, Scopus, and Google Scholar. The pooled effect size was estimated using a random-effects model with a 95 % confidence interval (CI). Subgroup analyses were used to evaluated differences in effect sizes according to pharmacist roles.

Result

A total of 10,998 studies were initially identified, of which 13 met the inclusion criteria. In eight pre-post studies, pharmacist involvement in immunisation services significantly increased vaccine uptake among older adults, yielding a pooled relative risk (RR) of 3.29 (95 % CI: 2.01–5.39). Similarly, in five randomised studies, pharmacist-led interventions were significantly associated with increased vaccine uptake, with a pooled RR of 3.04 (95 % CI: 1.46–6.34).

Conclusion

This review demonstrates the substantial impact of pharmacist-led interventions on vaccination uptake among older people. The findings suggest that the greatest improvements occur when pharmacists serve as educators, facilitators, immunisers, and advocators. Healthcare policymakers and organisations should prioritise and implement comprehensive pharmacist-led strategies to enhance vaccine uptake in this population.

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来源期刊

Research in Social & Administrative Pharmacy PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

7.20

自引率

10.30%

发文量

225

审稿时长

47 days

期刊介绍： Research in Social and Administrative Pharmacy (RSAP) is a quarterly publication featuring original scientific reports and comprehensive review articles in the social and administrative pharmaceutical sciences. Topics of interest include outcomes evaluation of products, programs, or services; pharmacoepidemiology; medication adherence; direct-to-consumer advertising of prescription medications; disease state management; health systems reform; drug marketing; medication distribution systems such as e-prescribing; web-based pharmaceutical/medical services; drug commerce and re-importation; and health professions workforce issues.