项目特异性编码缺陷指数与早期阿尔茨海默病内侧颞叶萎缩相关的诊断效用

IF 3.4 3区 医学 Q2 NEUROSCIENCES
Yen-Hsuan Hsu, Sheng-Min Huang, Li-Wei Kuo, Jir-Jei Yang, Min-Chien Tu
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引用次数: 0

摘要

考虑到编码缺陷可靠检测的挑战,本研究考察了项目特异性编码缺陷指数是否对早期阿尔茨海默病(AD)敏感,并探讨了其临床应用的神经基础。结果表明,该指数能显著预测早期AD患者的海马体积,尤其是在输入-处理子区。接受者工作特征分析证实了其区分极轻度AD患者与认知健康对照者的能力。该指数还显示了相对稳定的注意力相关的变化。这些发现支持其作为与AD相关的早期神经退行性变的行为生物标志物的潜在效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic utility of the item-specific Encoding Deficit Index in relation to medial temporal lobe atrophy in early-stage Alzheimer's disease.

Given the challenge of reliably detecting encoding deficits, this study examined whether the item-specific Encoding Deficit Index, presumably resistant to attentional fluctuations, is sensitive to early Alzheimer's disease (AD), and explored its neural basis for clinical application. Results showed that the index significantly predicted hippocampal volume in individuals with early-stage AD, especially in the input-processing subfields. Receiver operating characteristic analysis confirmed its ability to differentiate individuals with very mild AD from cognitively healthy controls. The index also demonstrated relative robustness against attention-related variability. These findings support its potential utility as a behavioral biomarker for early-stage neurodegeneration associated with AD.

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来源期刊
Journal of Alzheimer's Disease
Journal of Alzheimer's Disease 医学-神经科学
CiteScore
6.40
自引率
7.50%
发文量
1327
审稿时长
2 months
期刊介绍: The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.
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