Yen-Hsuan Hsu, Sheng-Min Huang, Li-Wei Kuo, Jir-Jei Yang, Min-Chien Tu
{"title":"项目特异性编码缺陷指数与早期阿尔茨海默病内侧颞叶萎缩相关的诊断效用","authors":"Yen-Hsuan Hsu, Sheng-Min Huang, Li-Wei Kuo, Jir-Jei Yang, Min-Chien Tu","doi":"10.1177/13872877251351612","DOIUrl":null,"url":null,"abstract":"<p><p>Given the challenge of reliably detecting encoding deficits, this study examined whether the item-specific Encoding Deficit Index, presumably resistant to attentional fluctuations, is sensitive to early Alzheimer's disease (AD), and explored its neural basis for clinical application. Results showed that the index significantly predicted hippocampal volume in individuals with early-stage AD, especially in the input-processing subfields. Receiver operating characteristic analysis confirmed its ability to differentiate individuals with very mild AD from cognitively healthy controls. The index also demonstrated relative robustness against attention-related variability. These findings support its potential utility as a behavioral biomarker for early-stage neurodegeneration associated with AD.</p>","PeriodicalId":14929,"journal":{"name":"Journal of Alzheimer's Disease","volume":" ","pages":"13872877251351612"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic utility of the item-specific Encoding Deficit Index in relation to medial temporal lobe atrophy in early-stage Alzheimer's disease.\",\"authors\":\"Yen-Hsuan Hsu, Sheng-Min Huang, Li-Wei Kuo, Jir-Jei Yang, Min-Chien Tu\",\"doi\":\"10.1177/13872877251351612\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Given the challenge of reliably detecting encoding deficits, this study examined whether the item-specific Encoding Deficit Index, presumably resistant to attentional fluctuations, is sensitive to early Alzheimer's disease (AD), and explored its neural basis for clinical application. Results showed that the index significantly predicted hippocampal volume in individuals with early-stage AD, especially in the input-processing subfields. Receiver operating characteristic analysis confirmed its ability to differentiate individuals with very mild AD from cognitively healthy controls. The index also demonstrated relative robustness against attention-related variability. These findings support its potential utility as a behavioral biomarker for early-stage neurodegeneration associated with AD.</p>\",\"PeriodicalId\":14929,\"journal\":{\"name\":\"Journal of Alzheimer's Disease\",\"volume\":\" \",\"pages\":\"13872877251351612\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Alzheimer's Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/13872877251351612\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Alzheimer's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13872877251351612","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Diagnostic utility of the item-specific Encoding Deficit Index in relation to medial temporal lobe atrophy in early-stage Alzheimer's disease.
Given the challenge of reliably detecting encoding deficits, this study examined whether the item-specific Encoding Deficit Index, presumably resistant to attentional fluctuations, is sensitive to early Alzheimer's disease (AD), and explored its neural basis for clinical application. Results showed that the index significantly predicted hippocampal volume in individuals with early-stage AD, especially in the input-processing subfields. Receiver operating characteristic analysis confirmed its ability to differentiate individuals with very mild AD from cognitively healthy controls. The index also demonstrated relative robustness against attention-related variability. These findings support its potential utility as a behavioral biomarker for early-stage neurodegeneration associated with AD.
期刊介绍:
The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.