2008年至2021年西西里岛呼吸道合胞病毒(RSV)住院:临床特征和严重程度预测因素

IF 3.2 3区 医学 Q1 PEDIATRICS
Anna Condemi, Domenico Marrali, Chiara Albano, Giulia Linares, Valeria Garbo, Giovanni Boncori, Laura Venuti, Antonio Cascio, Claudia Colomba
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引用次数: 0

摘要

背景:呼吸道合胞病毒(RSV)是引起毛细支气管炎的主要原因,每年全世界有360万人因急性下呼吸道感染住院,101400名5岁以下儿童死亡。在欧洲,婴儿因rsv相关住院的估计发生率为1.8%。我们描述了2008年至2021年间西西里岛(意大利)住院患者的RSV感染发生率,检查了RSV阳性患者的临床流行病学特征,并评估了与疾病严重程度相关的合并症。方法:回顾性收集标准出院记录(hdr)资料。采用逐步前向选择方法将单因素分析中的重要因素纳入多因素logistic回归,计算调整优势比(aORs)并确定ICU入院的独立危险因素。结果:总体而言,在研究时间框架内,4485例与rsv相关的住院患者,271例(6%)入住ICU, 8例死亡(0.2%)。大多数住院患者(86%)为婴儿(1岁以下),16.5%为新生儿(结论:rsv相关病理是西西里岛住院的重要原因,年龄小(特别是0-3个月)和合并症,包括营养和代谢紊乱(在儿科亚组中影响更大)和先天性心脏病是重要的预后预测因素。然而,考虑到rsv相关疾病仍然需要健康儿童和成人住院治疗,通过最新的流行病学研究继续监测rsv相关住院情况非常重要,这可以指导现有预防策略的实施,并为新策略的成本效益分析提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hospitalizations for respiratory syncytial virus (RSV) in Sicily from 2008 to 2021: clinical features and predictors of severity.

Background: Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis, resulting in 3.6 million hospitalizations for acute lower respiratory tract infections and 101,400 deaths in children under 5 years of age worldwide each year. In Europe, the estimated incidence of RSV-related hospitalizations in infants is 1.8%. We describe the incidence of RSV infection in patients hospitalized in Sicily (Italy) between 2008 and 2021, examine the clinical-epidemiological characteristics of RSV-positive patients, and assess comorbidities associated with illness severity.

Methods: All data were retrospectively collected from standard hospital discharge records (HDRs). Significant factors from the univariate analysis were included in a multivariate logistic regression using the stepwise forward selection method to calculate adjusted odds ratios (aORs) and identify independent risk factors for ICU admission.

Results: Collectively, within the study time frame, 4,485 hospital admissions were RSV-related, 271 patients (6%) were admitted to the ICU, and eight deceased (0.2%). The majority of hospitalized patients (86%) were infants (up to 1 year old), 16.5% were newborns (<28 days), and 10.1% were in the 1-4-year-old group. Several predictors of ICU admission, including neonatal sepsis, neonatal respiratory distress, and younger age (in months), were identified through multivariate logistic regression analysis.

Conclusions: RSV-associated pathologies are important causes of hospitalization in Sicily, and young age (particularly 0-3 months) and comorbidities, including nutritional and metabolic disorders (with a stronger effect in the pediatric subgroup) and congenital heart diseases, are important outcome predictors. However, considering that RSV-related diseases continue to require hospitalizations in healthy children and adults, it is important to continue monitoring RSV-related hospitalizations through updated epidemiological studies, which can guide the implementation of existing preventive strategies and inform the cost‒benefit analysis of new ones.

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来源期刊
CiteScore
6.10
自引率
13.90%
发文量
192
审稿时长
6-12 weeks
期刊介绍: Italian Journal of Pediatrics is an open access peer-reviewed journal that includes all aspects of pediatric medicine. The journal also covers health service and public health research that addresses primary care issues. The journal provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field. Italian Journal of Pediatrics, which commenced in 1975 as Rivista Italiana di Pediatria, provides a high-quality forum for pediatricians and other healthcare professionals to report and discuss up-to-the-minute research and expert reviews in the field of pediatric medicine. The journal will continue to develop the range of articles published to enable this invaluable resource to stay at the forefront of the field.
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