{"title":"树突性质对放电速率稳态中出现的离子通道相关性的影响:一项双室模型研究。","authors":"Guosheng Yi, Jiayi Cui, Ruifeng Bai","doi":"10.1007/s11571-025-10297-z","DOIUrl":null,"url":null,"abstract":"<p><p>Homeostatic regulation of firing rate is an important feature of neural excitability, which is achieved through feedback control of diverse ionic channel expression levels. The output firing rate is controlled by the active currents and passive properties of the dendrites. The objective of this study is to determine how dendritic properties affect the homeostatic regulation of somatic firing rate. We used a two-compartment Pinsky-Rinzel model to simulate action potentials in a pyramidal neuron in response to external inputs. We applied a feedback framework to determine the maximum ionic conductances during homeostatic regulation and examined the pairwise correlations among these conductances. We find that the effective regulation of somatic firing rate could be achieved through controlling both somatic and dendritic ionic channels. The correlations among these channels are lower than those emerging from the regulation through the control of somatic or dendritic channels. It is also shown that increasing the number of adjustable channels alters ionic channel correlations when the additional channel has a strong compensatory relationship with other channels. Compared to the coupling conductance between two compartments, varying the proportion of area occupied by the dendrite produces a greater effect on firing rate dynamics and expression correlations between adjustable channels in both dendrite and soma. The results reveal that dendritic ionic channels, morphological feature and dendritic-somatic coupling are all factors that influence the correlations in ionic channel expression. These findings provide a biophysical basis for the relationship between dendritic properties and neuronal information processing.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11571-025-10297-z.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"19 1","pages":"107"},"PeriodicalIF":3.1000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209171/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of dendritic properties on the correlations in ionic channels emerging from firing rate homeostasis: a two-compartment modeling study.\",\"authors\":\"Guosheng Yi, Jiayi Cui, Ruifeng Bai\",\"doi\":\"10.1007/s11571-025-10297-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Homeostatic regulation of firing rate is an important feature of neural excitability, which is achieved through feedback control of diverse ionic channel expression levels. The output firing rate is controlled by the active currents and passive properties of the dendrites. The objective of this study is to determine how dendritic properties affect the homeostatic regulation of somatic firing rate. We used a two-compartment Pinsky-Rinzel model to simulate action potentials in a pyramidal neuron in response to external inputs. We applied a feedback framework to determine the maximum ionic conductances during homeostatic regulation and examined the pairwise correlations among these conductances. We find that the effective regulation of somatic firing rate could be achieved through controlling both somatic and dendritic ionic channels. The correlations among these channels are lower than those emerging from the regulation through the control of somatic or dendritic channels. It is also shown that increasing the number of adjustable channels alters ionic channel correlations when the additional channel has a strong compensatory relationship with other channels. Compared to the coupling conductance between two compartments, varying the proportion of area occupied by the dendrite produces a greater effect on firing rate dynamics and expression correlations between adjustable channels in both dendrite and soma. The results reveal that dendritic ionic channels, morphological feature and dendritic-somatic coupling are all factors that influence the correlations in ionic channel expression. These findings provide a biophysical basis for the relationship between dendritic properties and neuronal information processing.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11571-025-10297-z.</p>\",\"PeriodicalId\":10500,\"journal\":{\"name\":\"Cognitive Neurodynamics\",\"volume\":\"19 1\",\"pages\":\"107\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209171/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cognitive Neurodynamics\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1007/s11571-025-10297-z\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cognitive Neurodynamics","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s11571-025-10297-z","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/30 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Effects of dendritic properties on the correlations in ionic channels emerging from firing rate homeostasis: a two-compartment modeling study.
Homeostatic regulation of firing rate is an important feature of neural excitability, which is achieved through feedback control of diverse ionic channel expression levels. The output firing rate is controlled by the active currents and passive properties of the dendrites. The objective of this study is to determine how dendritic properties affect the homeostatic regulation of somatic firing rate. We used a two-compartment Pinsky-Rinzel model to simulate action potentials in a pyramidal neuron in response to external inputs. We applied a feedback framework to determine the maximum ionic conductances during homeostatic regulation and examined the pairwise correlations among these conductances. We find that the effective regulation of somatic firing rate could be achieved through controlling both somatic and dendritic ionic channels. The correlations among these channels are lower than those emerging from the regulation through the control of somatic or dendritic channels. It is also shown that increasing the number of adjustable channels alters ionic channel correlations when the additional channel has a strong compensatory relationship with other channels. Compared to the coupling conductance between two compartments, varying the proportion of area occupied by the dendrite produces a greater effect on firing rate dynamics and expression correlations between adjustable channels in both dendrite and soma. The results reveal that dendritic ionic channels, morphological feature and dendritic-somatic coupling are all factors that influence the correlations in ionic channel expression. These findings provide a biophysical basis for the relationship between dendritic properties and neuronal information processing.
Supplementary information: The online version contains supplementary material available at 10.1007/s11571-025-10297-z.
期刊介绍:
Cognitive Neurodynamics provides a unique forum of communication and cooperation for scientists and engineers working in the field of cognitive neurodynamics, intelligent science and applications, bridging the gap between theory and application, without any preference for pure theoretical, experimental or computational models.
The emphasis is to publish original models of cognitive neurodynamics, novel computational theories and experimental results. In particular, intelligent science inspired by cognitive neuroscience and neurodynamics is also very welcome.
The scope of Cognitive Neurodynamics covers cognitive neuroscience, neural computation based on dynamics, computer science, intelligent science as well as their interdisciplinary applications in the natural and engineering sciences. Papers that are appropriate for non-specialist readers are encouraged.
1. There is no page limit for manuscripts submitted to Cognitive Neurodynamics. Research papers should clearly represent an important advance of especially broad interest to researchers and technologists in neuroscience, biophysics, BCI, neural computer and intelligent robotics.
2. Cognitive Neurodynamics also welcomes brief communications: short papers reporting results that are of genuinely broad interest but that for one reason and another do not make a sufficiently complete story to justify a full article publication. Brief Communications should consist of approximately four manuscript pages.
3. Cognitive Neurodynamics publishes review articles in which a specific field is reviewed through an exhaustive literature survey. There are no restrictions on the number of pages. Review articles are usually invited, but submitted reviews will also be considered.