T S S Teuntje van Es, B J M Bas Peters, G Gurbey Ocak, E A Elisabeth Kastelijn, S L Sabine Croonen, F C Floris Loeff, M P H Marcel van den Broek
{"title":"蛋白尿及其对单克隆抗体排泄的影响:1例派姆单抗病例报告及文献复习。","authors":"T S S Teuntje van Es, B J M Bas Peters, G Gurbey Ocak, E A Elisabeth Kastelijn, S L Sabine Croonen, F C Floris Loeff, M P H Marcel van den Broek","doi":"10.1007/s13730-025-01000-6","DOIUrl":null,"url":null,"abstract":"<p><p>Therapeutic monoclonal antibodies (mAbs) have revolutionized the treatment landscape of various diseases, offering targeted therapy options with high specificity. Under normal physiological conditions, their size prevents renal excretion. However, there is limited information about mAbs pharmacokinetics in patients with massive proteinuria, a condition often associated with a nephrotic syndrome. In this case report, we describe a 68-year-old man with non-small-cell lung carcinoma (NSCLC) and a paraneoplastic nephrotic syndrome, who was treated with pembrolizumab 200 mg every 3 weeks. Since there is limited data on pembrolizumab disposition in patients with nephrotic syndrome, we monitored pembrolizumab serum and urine concentrations to ensure adequate systemic exposure. Therapeutic drug monitoring results showed no renal excretion of pembrolizumab and therapeutic drug exposure. Treatment of the NSCLC led to an amelioration of the paraneoplastic nephrotic syndrome. We conducted a literature review on the various types of proteinuria and their effects on the excretion of mAbs. Existing literature shows that increased renal clearance of monoclonal antibodies in patients with glomerular proteinuria is possible, but it probably depends on the amount of glomerular proteinuria. Based on literature findings and our own, we suggest that in cases of severe glomerular proteinuria, like nephrotic range proteinuria, the likelihood of renal loss of monoclonal antibodies is higher than in other cases.</p>","PeriodicalId":9697,"journal":{"name":"CEN Case Reports","volume":" ","pages":"757-763"},"PeriodicalIF":0.7000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457255/pdf/","citationCount":"0","resultStr":"{\"title\":\"Proteinuria and influence on monoclonal antibody excretion: a pembrolizumab case report and literature review.\",\"authors\":\"T S S Teuntje van Es, B J M Bas Peters, G Gurbey Ocak, E A Elisabeth Kastelijn, S L Sabine Croonen, F C Floris Loeff, M P H Marcel van den Broek\",\"doi\":\"10.1007/s13730-025-01000-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Therapeutic monoclonal antibodies (mAbs) have revolutionized the treatment landscape of various diseases, offering targeted therapy options with high specificity. Under normal physiological conditions, their size prevents renal excretion. However, there is limited information about mAbs pharmacokinetics in patients with massive proteinuria, a condition often associated with a nephrotic syndrome. In this case report, we describe a 68-year-old man with non-small-cell lung carcinoma (NSCLC) and a paraneoplastic nephrotic syndrome, who was treated with pembrolizumab 200 mg every 3 weeks. Since there is limited data on pembrolizumab disposition in patients with nephrotic syndrome, we monitored pembrolizumab serum and urine concentrations to ensure adequate systemic exposure. Therapeutic drug monitoring results showed no renal excretion of pembrolizumab and therapeutic drug exposure. Treatment of the NSCLC led to an amelioration of the paraneoplastic nephrotic syndrome. We conducted a literature review on the various types of proteinuria and their effects on the excretion of mAbs. Existing literature shows that increased renal clearance of monoclonal antibodies in patients with glomerular proteinuria is possible, but it probably depends on the amount of glomerular proteinuria. Based on literature findings and our own, we suggest that in cases of severe glomerular proteinuria, like nephrotic range proteinuria, the likelihood of renal loss of monoclonal antibodies is higher than in other cases.</p>\",\"PeriodicalId\":9697,\"journal\":{\"name\":\"CEN Case Reports\",\"volume\":\" \",\"pages\":\"757-763\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457255/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CEN Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s13730-025-01000-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CEN Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s13730-025-01000-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/2 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Proteinuria and influence on monoclonal antibody excretion: a pembrolizumab case report and literature review.
Therapeutic monoclonal antibodies (mAbs) have revolutionized the treatment landscape of various diseases, offering targeted therapy options with high specificity. Under normal physiological conditions, their size prevents renal excretion. However, there is limited information about mAbs pharmacokinetics in patients with massive proteinuria, a condition often associated with a nephrotic syndrome. In this case report, we describe a 68-year-old man with non-small-cell lung carcinoma (NSCLC) and a paraneoplastic nephrotic syndrome, who was treated with pembrolizumab 200 mg every 3 weeks. Since there is limited data on pembrolizumab disposition in patients with nephrotic syndrome, we monitored pembrolizumab serum and urine concentrations to ensure adequate systemic exposure. Therapeutic drug monitoring results showed no renal excretion of pembrolizumab and therapeutic drug exposure. Treatment of the NSCLC led to an amelioration of the paraneoplastic nephrotic syndrome. We conducted a literature review on the various types of proteinuria and their effects on the excretion of mAbs. Existing literature shows that increased renal clearance of monoclonal antibodies in patients with glomerular proteinuria is possible, but it probably depends on the amount of glomerular proteinuria. Based on literature findings and our own, we suggest that in cases of severe glomerular proteinuria, like nephrotic range proteinuria, the likelihood of renal loss of monoclonal antibodies is higher than in other cases.
期刊介绍:
Clinical and Experimental Nephrology (CEN) Case Reports is a peer-reviewed online-only journal, officially published biannually by the Japanese Society of Nephrology (JSN). The journal publishes original case reports in nephrology and related areas. The purpose of CEN Case Reports is to provide clinicians and researchers with a forum in which to disseminate their personal experience to a wide readership and to review interesting cases encountered by colleagues all over the world, from whom contributions are welcomed.