Clinicopathological observation and prognostic factors of invasive breast cancer with medullary in Xinjiang.

Background: Invasive breast cancer (BC) with medullary is a special type of BC, accounting for 3 ~ 6% of invasive BC. To investigate clinicopathological characteristics concerning invasive BC with medullary in Xinjiang area and analyze the prognostic factors of patients.

Materials and methods: Clinicopathological data of100 invasive BC patients with medullary admitted to Xinjiang tumor Hospital from January 2011 to December 2020 were analyzed retrospectively via R packages. Count data were analyzed applying COX regression model and relevant statistics approaches.

Results: All 100patients that investigated were female and the median age was 48 years old. The median follow-up time was 92 months. The the cumulative disease free survival (DFS) at 10 years were 84.1%. Log-Rank test results suggest that ethnicity, TNM stage, tumor size, lymph node metastasis, and pathological type are possible adverse factors affecting patients with invasive breast cancer with myeloid features (P<0.05).

Conclusion: Despite the poor pathological features of Invasive BC with medullary, its clinical outcome is more favorable. Ethnicity, TNM stage, tumor size, lymph node metastasis, and pathological type are possible adverse factors affecting patients with invasive breast cancer with medullary features.